Senior Scientist, Biophysics & AAV Analytics

Pfizer
Cambridge, Massachusetts
Competitive
December 03 2021
4830457
Full Time
Pharma
Senior Scientist
ROLE SUMMARY

We are seeking a highly motivated Senior Scientist to join the Molecular Assessment and Profiling group in BioMedicine Design. This individual will plan, execute, and provide in-depth biochemical and biophysical characterization of AAV viral vectors and AAV capsids. This person will work with the biophysics team to drive GTx innovation, novel assays, and technology development. Successful candidate will work in a fast-paced environment managing multiple projects, and work with project teams to contribute to the development of GTx therapeutics.

ROLE RESPONSIBILITIES
  • Perform molecular characterization, biophysical analysis, and stability assessment of GTx AAV and next gen designs; will work on a wide range of assays
  • Critically analyze and present experiment results across multiple teams spanning general to subject expert audiences
  • Provide scientific guidance and decision to move projects along discovery pipeline
  • Drive technology innovation; evaluate new technologies and instrumentations
  • Work closely with cross-functional teams including therapeutic discovery teams, production groups, MS, and development organization to plan and execute deliverables


Qualifications

Must-Have

  • A PhD with 0-3 years of relevant experience in Biochemistry, Biophysics, or related discipline
  • Extensive hands-on experience with a wide range of biophysical protein characterization techniques such as cGE, SEC, MALS, DLS, AUC, cIEF
  • A solid understanding of protein biochemistry and stability
  • Ability to multi-task multiple projects with overlapping timelines.
  • Excellent communication, presentation, and documentation skills


Nice-to-Have

  • Knowledgeable with various DNA analysis methods such as q/ddPCR, gel-based separation, Tapestation
  • Prior experience with viral vectors and/or AAV analytics is desirable
  • Demonstrated track record of independent research and scientific publications in peer review journals


PHYSICAL/MENTAL REQUIREMENTS
  • Must be able to stand for ~1 hours at a time and must be able to analyze complex data.


Other Job Details:
  • Eligible for Employee Referral Bonus


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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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