Senior Scientist, Cell Line Development

Pfizer
Chesterfield, Missouri
Competitive
February 28 2021
4805538
Full Time
Pharma
Senior Scientist
ROLE SUMMARY

Pfizer's Cell Line Development (CLD) organization is seeking a highly motivated and highly qualified candidate to be a technical leader, in a lab-based Senior Scientist role. The successful candidate will have the opportunity to perform platform technology development activities, which advances Pfizer's biotherapeutics pipeline toward clinical and commercial development. The position will be involved in the advancement of the entire biologics portfolio, including mammalian recombinant protein expression, viral vectors and other modalities, as well as novel technology and process optimization programs. This role will focus on the molecular biology component of cell line development with an emphasis on RNA biology and vector design. Additional skillsets in mammalian cell biology, including cell culture maintenance, clone screening, flow cytometry, and cell line characterization are also desired. The successful candidate will help to design and drive innovative improvements to CLD technologies, practices and infrastructure to ensure successful delivery of the project portfolio and continuous technology improvements. In addition, experience with systems biology, synthetic biology, bioinformatics, and/or automation technologies is desired.

ROLE RESPONSIBILITIES
  • Be a key member of the CLD team that will support the execution of both technology development and pipeline projects.
  • Demonstrate outstanding communication and presentation skills, a documented ability to troubleshoot technical issues, an ability to plan and carry out experiments independently, and to work with complex instrumentation and software.
  • Effectively document all lab activities in notebooks/elsewhere as required and appropriate, in a timely fashion; author technical reports as needed and contribute to posters and publications as appropriate.
  • Evaluate data and provide clear reports that can be shared and transferred to and from cross-functional teams; responsible for clear communication in both written and oral forms.
  • Adherence to safety protocols and knowledge of basic laboratory procedures to advance projects under rapidly shifting priorities and timelines.
  • Work closely with groups outside of the CLD organization to advance portfolio and technology development initiatives.
  • Work with and contribute to associated regulatory filing activities.
  • Support laboratory activities by monitoring lab equipment and maintaining a clean and safe working environment.


BASIC QUALIFICATIONS
  • Requires Ph.D. in cell/molecular biology or related field with 0-4 years' experience or a Master's Degree with 5+ years' experience in the area of mammalian cell line development and/or molecular biology.
  • Highly productive, technical scientist and leader, who applies extensive technical and scientific knowledge as well as practical experience to deliver high quality results to drive delivery of CLD programs.
  • Substantial experience with molecular biology including:
    • Plasmid construction, preparation and analysis.
    • RNA transcription reactions, purification, stability and analytics.
    • cDNA and genomic DNA preparation, sequencing (Sanger and Next Gen).
    • DNA electrophoresis as well as Northern and Southern analyses.
  • Outstanding oral and written communications skills.
  • Strong analytical and computer skills are required.
  • Growth potential to take on larger leadership roles.
  • Self-motivated individual who works well in a team setting.


PREFERRED QUALIFICATIONS
  • Experience with mammalian cell culture techniques is highly desired.


Other Job Details:
  • Last Date to Apply for Job: March 5, 2021
  • Eligible for Employee Referral Bonus: YES


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