In Vivo Imaging Investigator

Collegeville, PA
January 22 2021
Other, Other
The successful candidate is interested in delivering imaging biomarkers to support drug discovery and development efforts. The primary goal of this position will be to further develop the nuclear imaging capabilities internally and externally (working with academic institutions, CRO's). This work will be used to better inform drug discovery teams regarding optimal molecule and dose selection. Additionally, this work will help reduce attrition in the clinic by providing whole body biodistribution profiles of molecules and target engagement within organs and understand safety concerns leading up to first time in human studies. The successful candidate will have the opportunity to work with a diverse group of biologists and pharmacologists as well as with an experienced team of imaging scientists at GSK. There will be opportunity to learn and employ additional non-invasive imaging modalities to address the needs of the drug discovery programs.

Key Responsibilities:
  • Perform in vivo imaging studies (study design, protocol, data acquisition, and image analysis) to support the needs of Discovery Research and business partners ranging from drug design through safety evaluation to product/device development.
  • Develop radiochemistry methods for the preparation of radiolabeled large molecules.
  • Develop and execute analytical methods for the characterization of radiolabeled compounds, using techniques such as radio-TLC and radio-HPLC, LC-MS, etc.
  • Responsible for study support and data generation/management and communication to project/program teams.
  • Responsible for managing in-vivo imaging studies performed with external collaborators (academic centers, and CROs).
  • Ensure radiation safety during nuclear imaging studies.
  • Responsible for animal care and use protocol writing and oversight of the animal imaging protocols.
  • Assure high standards for animal care and compliance with all federal, state, and local regulations.
  • Maintain compliance with company and departmental policies and procedures.
  • Responsible for implementing and maintaining instrument QC and service contracts with imaging vendors.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • Ph.D. in Chemistry, Physics, Biophysics, or similar
  • Minimum of 2 years of post-doctoral and/or industrial experience working with non-invasive nuclear imaging technologies
  • Experience in performing small and large animal nuclear imaging
  • Experience with data acquisition, and image analysis for assessing disease modification, biomarker development, and clinical translation.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:
  • E xperience with radiochemistry for large molecules
  • Have training in integrative physiology and/or pharmacology.
  • Ability to work well in a team environment and excellent written & oral communication skills.

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness


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