Post-Docs in the Virgil Percec lab at the University of Pennsylvania, Department of Chemistry

Post-docs in the Virgil Percec Lab at the University of Pennsylvania (Penn), Department of Chemistry in the design, synthesis and structural analysis combined with  in vivo activity for one-component delivery systems for mRNA

Virgil Percec Lab together with Drew Weissman Lab from the Perelman School of Medicine at Penn discovered and developed a one-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA (JACS 2021, 143, 12315). IAJDs co-assemble with mRNA into dendrimersome nanoparticles (DNPs) which eliminate some of the disadvantages and complement the four-component lipid nanoparticles (LNPs) elaborated and employed in the delivery of mRNA from Covid 19 vaccines. These postdoc positions are immediately available and require excellent background in organic synthesis, supramolecular chemistry and characterization by  NMR, HPLC, MALDI-TOF combined with in vivo experiments performed in collaboration with Weissman Laboratory. The goal of these positions is to develop a Nanoperiodic Table correlating the primary structure of IAJDs with in vivo mRNA delivery. This work is expected to impact the new field of nanomedicine by creating new, less expensive and more activer vaccines and therapeutics based on mRNA