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Postdoctoral Fellow in Cancer Biology and Biomedical Engineering

Employer
Sanford Research
Location
Sioux Falls, South Dakota
Salary
Commensurate with experience following the NIH NRSA Stipend Scale
Closing date
Mar 22, 2025
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Job Details

Postdoctoral position is available in the laboratory of Prof. Pilar de la Puente, Sanford Research, Sioux Falls to study dynamics of dysregulation of the extracellular matrix (ECM) composition in cancer. Dr. de la Puente lab’s mission is focused on the engineering of translational and physiologically relevant preclinical cancer models to advance cancer research. (https://delapuentelab.com/). The de la Puente Lab develops translational and physiologically relevant preclinical cancer models as tools to recapitulate tumor behavior ex vivo (“out of the living”) with an emphasis in cellular crosstalk, extracellular matrix remodeling, and spatial gradients. We focus on elucidating mechanisms driving chemoresistance and immune evasion in cancer and further developing novel treatment strategies to mitigate their occurrence. Our long-term goal is to accelerate and directly translate our significant insights to aid patients suffering from cancer. 

Requirements: 
Interested candidate is expected to have recently obtained a PhD in Biomedical Engineering, Biology or similar discipline and be a first author on at least 1-2 publications in Cancer, cell-ECM mechanotransduction, and/or biomedical engineering applications. The main job duty is to perform research to understand the role of tumor extracellular matrix remodeling in cancer chemoresistance and to identify novel therapeutic targets by using patient-derived 3D cultures (Funding already secured). The translational research project leverages multi-disciplinary approach in cancer biology, bio-orthogonal metabolic labeling, biomedical engineering/tissue engineering, mechanotransduction signaling, OMICs, and high-throughput in vitro patient-derived models to probe complex biological processes and to pursue new therapeutic opportunities for cancer. Experience in 3D tissue cultures, confocal imaging and/or cancer biology is preferred. Excellent oral and written communication skills in English are required. Our laboratory is an inclusive and supportive environment, and we strongly encourage motivated individuals from historically excluded groups in science to apply. 

How to apply: 
Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to: pilar.puente@sanfordhealth.org 

Contact: 
Pilar de la Puente, PhD; pilar.puente@sanfordhealth.org 
Cancer Biology and Immunotherapies, Sanford Research 
https://delapuentelab.com/ 

Company

Sanford Research is the research arm of Sanford Health, one of the largest rural integrated health care systems in the nation. This makes Sanford Research uniquely structured to facilitate basic, translational, clinical, and population health research across the upper Midwest and the entire Sanford Health network.

Faculty have access to state-of-the-art facilities and unique resources. New staff will join a team with a well-established infrastructure in basic, translational, and behavioral sciences research and strong faculty mentorship. Sanford Research has a long history of successful extramural funding and receives substantial NIH funding. Currently, we have three NIH-funded Centers of Biomedical Research Excellence (CoBRE) with focuses in pediatriccancer, and population health research.

Innovation, discovery and passion drive our talented scientists, who are dedicated to finding cures, eradicating disease and improving the lives of people around the world through scientific breakthroughs.

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