Staff Scientist: Systems Biology, Computational Biology, and Epigenome Biology

National Heart, Lung, and Blood Institute

National Institutes of Health (NIH)

Department of Health and Human Services

Staff Scientist: Systems Biology, Computational Biology, and Epigenome Biology  

The National Heart, Lung, and Blood Institute (NHLBI), Division of Intramural Research (DIR) seeks to hire a Staff Scientist to pursue research in Systems Biology, Computational Biology, Epigenomics, and Immunology within the Laboratory of Epigenome Biology of in the Systems Biology Center (SBC)  (https://www.nhlbi.nih.gov/science/epigenome-biology).

The applicant must have a Ph.D. or equivalent in bioinformatics, computational biology, or computer science; demonstrated experience in developing tools for NGS data analysis; strong programming skills in Python, C/C++, MATLAB, or similar languages for algorithm development and implementation. The applicant should have a strong publication record in peer-reviewed journals, demonstrating contributions to the field of Epigenomics or epigenetic regulation of immune systems. 

The applicant will join a unique multidisciplinary team of computational and experimental scientists, to study immune memory, cellular differentiation, and pathological conditions using genomics, epigenomics and systems biology approaches. Our laboratory has developed the ChIP-Seq, MNase-Seq, single-cell DNase-seq, scMNase-seq, ACT-seq, scChIC-seq, and Hi-TrAC techniques to analyze genome-wide distribution of chromatin modifications and DNA-binding factors (Cell, 2007, 2008, 2009, 2012; Nature 2015, 2018; Nature Methods 2018, 2019; Nature Comm. 2022; Immunity 2022, 2023, 2024). The application of these techniques to mammalian cells has provided insights into the roles of various chromatin modifications and functions of various chromatin-modifying enzymes, such as histone acetyltransferases and deacetylases as well as ATP-dependent chromatin remodeling complexes, in cellular differentiation and cellular memory formation. We are studying the contribution of two-dimensional and three-dimensional nuclear structure in cells. Future studies will investigate the function and regulation of epigenetic mechanisms and three-dimensional nuclear structure in normal development and diseases at a single-cell resolution, particularly in the immune system.

Appointees may be US citizens, resident immigrants, or non-resident immigrants with or eligible to obtain a valid employment authorized visa.  Applications from women, minorities and persons with disabilities are strongly encouraged.

TO APPLY: Applicants should submit the following: 1) cover letter highlighting key qualifications and long term career goals; 2) current curriculum vitae with complete bibliography; and 3) three letters of reference (via email only) to:

Maria G. Stoltzfus

gonzamar@mail.nih.gov

The review of applications will begin on rolling basis as complete application packages are submitted.  Applications will be accepted until the position is filled.

DHHS and NIH are Equal Opportunity Employers. Positions are subject to a background check

The NIH is dedicated to building a diverse community in its training and employment programs

Salary is commensurate with education and experience and a full Civil Service package of benefits (including retirement, health, life, and long-term care insurance, and a Thrift Savings Plan) is available. There are also programs at the NIH to provide parental leave, as well as opportunities for on-site childcare.  The research is funded by the intramural research program and does not require applications for grants or external support.