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Special Postdoctoral Fellow in Cell Surface Receptors and Transmembrane Signaling

Employer
Springer Lab at BCH
Location
Boston, Massachusetts (US)
Salary
$78,000/annually + benefits
Closing date
Jan 11, 2025
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Job Details

Join the Lab of Tim Springer
Tim Springer, a leader in integrin biology, invites aspiring scientists to join his lab to advance groundbreaking research in integrin transmembrane signaling, TGF-β activation, cell surface receptor mechanobiology, and therapeutic development. This role offers mentorship and opportunities to establish a strong scientific foundation for launching an independent research career.

 

About the Role:

As a Special Postdoctoral Fellow, you will:

  • Pursue cutting-edge research in areas such as:
  • Novel integrin ligands to drive stem cell and organoid development
  • Cryo-EM: Activation of integrins and TGF-β, and ligand binding
  • Mechanobiology: Integrin force transduction in rolling adhesion and firm adhesion and TGF-β activation
  • Single Molecules: Utilize advanced techniques including FRET and magnetic tweezers to explore conformational change kinetics and force transmission in integrins and selectins
  • Innovative ReaLiSM: (Receptor and Ligand in Single Molecules) to study receptor-ligand binding dynamics
  • TGF-β Activation: Research localized activation at cell surfaces for new therapeutic targets
  • Own and Develop Your Project: We encourage candidates to propose and develop their own research ideas, which they can carry forward to establish their own labs.

 

Key Techniques and Approaches:

  • Single-molecule imaging
  • Cryo-EM
  • Organoid and stem cell research
  • FRET reporters using non-canonical amino acids
  • Magnetic and laser tweezers
  • Mechanobiology and therapeutic target discovery

 

Why Join Us?

  • Mentorship from Tim Springer, renowned for his pioneering work in integrins and cell biology
  • Independence and Growth: Develop projects that will empower your transition to an independent research career
  • Collaborative Environment at Harvard Medical School and Boston Children’s Hospital

 

Application Details: To apply, please email the following to springer_jobs@crystal.harvard.edu with "Special Postdoctoral Fellow" in the subject line:

  1. Cover letter (include a brief outline of your project interests)
  2. CV
  3. Three references

 

Salary: $78,000 annually

Qualified applicants will receive consideration without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status, or disability.

Company

My lab studies receptor-ligand interactions and signal transmission across membranes. We use a wide range of structural, cell biological, and single molecule techniques to answer important questions relevant to immunology, hemostasis, mammalian biology, and human disease.

Our interests include:

  • Integrins and how they communicate extracellular ligand binding to cytoskeleton assembly and force transduction
  • cryoEM of integrin-ligand complexes (with Alan Brown)
  • Single molecule studies of conformational change kinetics and force transmission (with TJ Ha)
  • Transforming growth factor β and its localized activation at cell surfaces by integrins and proteases
  • Stem cells and developmental pathways
  • Nervous system development and microglia
  • Tyrosine kinases and inside-out signals transmitted by them in transformed cancer cells
  • Therapeutics development using deep biological insights into cell surface receptor conformational change
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