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Postdoctoral Scientist

Employer
Stanford University - Schuele lab
Location
Stanford, California (US)
Salary
FY25 minimum is $73,800
Closing date
Sep 26, 2024
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Join Our Diverse and Interdisciplinary Team as a Postdoctoral Scholar!

We are excited to invite you to become a part of our research team! We are seeking a highly motivated Postdoctoral Scholar to contribute to a cutting-edge research project focused on brain resilience using human iPSC models and multi-omics approaches. This collaborative project will be conducted within the Departments of Pathology and Neurology & Neurological Sciences.

About the Project:

Brain resilience refers to the capacity to resist adverse outcomes despite significant risk factors. In late-onset Alzheimer’s disease (AD), Apolipoprotein E4 (APOE4) is recognized as the most significant genetic risk factor. Individuals carrying one copy of APOE4 have approximately a 4-fold increased risk of developing AD, while those with two copies face a 15-fold increased risk compared to carriers of the ApoE3 allele. Despite this, a subset of APOE4 carriers exhibits resilience, maintaining cognitive function despite the presence of disease pathology.

This research project aims to develop human iPSC-derived central nervous system (CNS) cell types from APOE4 donors associated with both risk and resilience. We will perform comprehensive multi-omic and functional profiling of these cell cultures to uncover the biological mechanisms underlying resilience in APOE4 carriers.

EDUCATION AND EXPERIENCE:

● PhD in neuroscience, life sciences

KNOWLEDGE, SKILLS, AND ABILITIES:

● Extensive tissue culture laboratory experience (at least 1 year) is required. Good laboratory practices and sterile culture techniques are critical.

 

● Ability to undertake and complete large research projects and communicate findings to the field as demonstrated by first author publications in respected journals and oral conference presentations.

● Experience culturing and maintaining human iPSCs and neuronal and/or microglia differentiation using iPSCs.

● Experience in cellular assays (e.g., human iPSC-derived neurons) and high-throughput format.

● Experience with immunocytochemistry, confocal microscopy, and image analysis is strongly preferred. Experience with molecular biology and biochemistry techniques such as DNA/RNA extraction, PCR, cloning, protein extraction, and Western blot.

● Experience omics data analysis and data integration.

● Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.

● Ability to maintain detailed records of experiments and outcomes.

● Excellent organizational skills and demonstrated ability to accurately complete detailed work.

In addition, preferred requirements include:

● Strong analytical skills and excellent judgment.

● Ability to work under deadlines with general guidance is essential.

● The candidate should be able to work independently, be highly motivated, collaborative, well organized, adaptable and work well within an interdisciplinary and international team.

● Good communication and interpersonal skills are essential

WORKING CONDITIONS:

● May require working in close proximity to blood borne pathogens.

● May require work in an environment where animals are used for teaching and research.

● Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.

● Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.

● May require extended or unusual work hours based on research requirements and business needs.

 

The expected base pay for this position is the Stanford University required minimum for all postdoctoral scholars appointed through the Office of Postdoctoral Affairs. The FY25 minimum is $73,800.

Stanford University is an affirmative action and equal opportunity employer, committed to increasing the diversity of its workforce. It welcomes applications from women, members of minority groups, veterans, persons with disabilities, and others who would bring additional dimensions to the university's research and teaching mission.

Applicants should submit their CV, a letter outlining interest and motivations, and names and contact information of two references to bschuele@stanford.edu

 

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