Skip to main content

This job has expired

Pharmacometrics Oncology Group Lead, Executive Director

Pearl River, New York, United States;New York City, New York, United States; Collegeville, Pennsylvania, United States;Cambridge, Massachusetts, United States;
Closing date
Jul 11, 2024

View more

Life Sciences, Oncology
Position Type
Full Time
Job Type
Organization Type

Supporting Pfizer Oncology, you will be a senior scientific and strategic leader and a member of the Pharmacometrics and Systems Pharmacology Leadership Team. In this key role, you will influence the discovery and development of drugs and expand the application of model-informed drug development (MIDD) approaches within oncology and across our portfolio.

You will lead a team of talented pharmacometricians to evaluate risk/benefit and facilitate drug development decisions by constructing, validating, and utilizing disease, placebo, exposure-response, and mechanistic PKPD models and other quantitative approaches. You will partner with key stakeholders and colleagues in Clinical Pharmacology, Quantitative Systems Pharmacology, Statistics, Translational Modeling and Simulation, and other Research and Development lines to accelerate breakthrough cancer medicines that bring new hope to patients everywhere.

  • Provide scientific, technical, and strategic leadership of the pharmacometrics function within oncology, and other therapeutic areas as appropriate/needed.
  • Provide oversight to the development of Model Informed Drug Development (MIDD) plans, involving planning and execution of quantitative analyses which may include population pharmacokinetics, pharmacokinetics (PK)/pharmacodynamics (PD), exposure response, disease progression modeling, model-based meta-analysis, and decision analysis. As needed, may develop individual MIDD plans and conduct the quantitative analyses.
  • Manage a large team of Pharmacometricians and/or other Computational Scientists.
  • Train, develop, and mentor pharmacometricians and other MIDD colleagues.
  • Forecast pharmacometrics resourcing needs within the oncology therapeutic area.
  • Provide guidance to our regulatory MIDD strategy
  • Contribute to the development or improvement of our tools, processes and methodology, including involvement in internal cross-functional workgroups or initiatives, external alliances or committees, consortia and academic relationships.
  • Influence and lead the external environment through scientific societies, publications, presentations, and collaborations.

  • PhD in Pharmaceutical Science, Math or related discipline or PharmD
  • Strong quantitative experience (e.g., pharmacometrics, pharmacokinetics/pharmacodynamics, quantitative systems pharmacology, statistics)
  • Minimum 10 years of pharmacometrics experience, including pharmacometics modeling in a drug development setting
  • Experience managing a team of colleagues with advanced degrees (e.g., Ph.D., PharmD) including colleague development and performance management
  • Proficient with pharmacometrics analysis and related software (e.g., NONMEM, R)
  • Experience presenting pharmacometrics modeling analyses and data, and MIDD plans and strategies to various audiences in both verbal and written form;
  • Experience writing pharmacometrics modeling results, interpretations (including impact) and conclusions for reports and regulatory documents that are clear and concise;
  • Experience applying appropriate FDA and ICH guidelines in the design of MIDD plans and analyses, and preparation of pharmacometrics components of regulatory submissions and inquiries.

  • Pharmacometrics experience applied to oncology drug development
  • Experience supporting pharmacometrics analyses for large and small molecules, including anti-body drug conjugates, bsAB, tsAb, and novel modalities.
  • Strong track record of publications

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers and key stakeholders, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.


Occasional travel (several times/year), as needed.

Ability to regularly attend meetings during business hours on US Pacific time.


The annual base salary for this position ranges from $226,200.00 to $377,000.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 25.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.


Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert