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Senior Associate Scientist, Process Safety

Groton, Connecticut
Closing date
Jun 28, 2024

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Health Sciences, Drug Development, Other, Manufacturing/QA/QC
Position Type
Full Time
Job Type
Staff Scientist
Organization Type

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.


We are seeking a chemical engineer/chemist to join the Chemical Research and Development (CRD) Process Safety team in Groton. They will apply safety specific principles and generate lab-scale data-rich experimentation to increase process understanding and to assess safe process operating conditions.

CRD, as part of Worldwide R&D in Pharmaceutical Sciences, is responsible for the development of process technology for the production of API. CRD scientists engage in all facets of development from small scale synthesis in support of medicinal chemistry programs, to the development of the commercial synthetic route. CRD scientists partner with manufacturing specialists for API synthesis in kilo-lab and pilot plant facilities, as well as provide support for technology transfer to Pfizer manufacturing sites and third party facilities.

You will collaborate with process chemists, engineers, and process supervisors to develop an acceptable basis for safety to support scale-up and technology transfer of new chemical processes to Pfizer's research and manufacturing facilities. The scope of work includes the development and execution of a suitable process safety testing plan following established guidelines, best practices, and scientific judgment. Instrumentation used in the analysis of process safety includes, but is not limited to, Differential Scanning Calorimetry (DSC), Accelerating Rate Calorimetry (ARC), Thermal Screening Unit (TSU), and reaction calorimetry. The candidate will also help advance both in-silico and experimental tools and techniques the group uses to execute projects.

  • Working with process chemists and engineers, perform the careful and thorough evaluation of all known and potential hazards for the safe scale-up of chemical processes for preparing pharmaceutical intermediates and active products in Pfizer research and manufacturing facilities
  • Remain current on process safety science and technology. Maintain active involvement in key professional societies through conference participation and publication
  • Develop a safety test plan suitable for the potential process hazards and perform all required process safety testing. Typical testing includes DSC, ARC, TSU, and reaction calorimetry (RC-1 and CRC) to identify and characterize all thermal and pressure events of the intended and unintended processes
  • Identify all requirements for external safety testing (e.g. dust explosivity) and lead engagement with external vendors and coordinate all interactions
  • Identify and characterize reaction off-gas rates
  • Enter all experimental data and calculations in an electronic laboratory notebook and in collaboration with other process safety colleagues, complete review and witnessing of all experiments.
  • Summarize and document results in process safety test reports
  • Lead technology development and workflow initiatives to implement new capabilities and improve efficiency

  • BS/MS in Chemical Engineering/Chemistry or related scientific field with 2-3 years' experience (BS) or no previous experience (MS).
  • E xcellent knowledge of chemical engineering principles including; reaction kinetics, chemical thermodynamics, heat and mass transport, engineering statistics, reactor design.
  • Strong attention to detail in experimentation and documentation
  • Excellent interpersonal and communication skills and proven track record for working with diverse groups of scientists.
  • Ability to work independently on projects with some supervision.

  • Experience in thermal analysis techniques; including DSC, ARC, and reaction calorimetry.
  • Experience using automated laboratory reactors and associated equipment (dosing pumps, pH meters, etc)
  • Working knowledge of reaction modeling, property prediction, and simulation computational tools including: DynoChem, Visimix, Aspen, and Cosmotherm
  • A good foundational understanding of organic chemistry

  • Ability to work in a laboratory environment performing experiments in a laboratory fume hood. Ability to perform complex data analysis.

  • Some travel associated with technology transfer to CRD scale-up facilities, and PGS new product launch site may be required.
  • Relocation support available
  • Work Location Assignment:On Premise

The annual base salary for this position ranges from $64,600.00 to $107,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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