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ERS Chemistry Sourcing Lead

Cambridge, Massachusetts, United States;Groton, Connecticut, United States;
Closing date
Jun 21, 2024

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Life Sciences, Analytical Chemistry
Position Type
Full Time
Organization Type
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Senior Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be part of a group in Pfizer comprises experts in the major scientific disciplines involved in the discovery and preclinical development of small molecule drugs. Specifically, you will be involved in molecular design, synthesis, computational chemistry, pharmacology, chemical biology, structural biology, analytical chemistry etc.

You will play a vital role as a key contributor in large, multi-disciplinary matrix teams from project inception through to delivery of clinical drug candidates. You will provide key contributions to the implementation of medicinal chemistry strategies through development and execution of innovative synthetic chemistry and help to revolutionize our approach to the discovery and development of small molecule and synthetically-derived drugs.

You will be recognized as a technical expert and a scientific contributor. With your deep knowledge of the discipline, you will be an active team member whose decisions impact the project. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience.

Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide team members.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.


The Chemistry Sourcing Lead, External Research Solutions will work alongside the local/global chemistry leaders/RPLs/SMTs/client groups to ensure effective utilization of the external resources for RU-based programs. This role will provide operational/logistics support for the assigned RU across Med Design. The role will support integration of compounds and data rom collaborators/CROs/Pfizer subsidiaries.

This colleague will collaborate with ERS staff locally/globally to oversee chemistry sourcing activities (FFS/FTE/milestones/external collaborations) and guide chemistry teams on sourcing capabilities, and to share best practices across RU as a member of the global ERS community. You will serve as the primary link of the chemistry lines on issues related to external sourcing capabilities, operational enablement and to ensure alignment of the global resources against RU needs.

This colleague will interface will multiple divisions and Operation groups to enable effective and efficient process for sourcing to integrate services from CROs. As needed, to work in partnership with RU Chemistry, PSSM-CRD and SMTs to support their sourcing needs. Working with CROs as the interface to facilitate communication, productivity enablement and operation efficiency and as needed, will support the alliance management of key technologies to support Med Design collaborations (academics/biotech).


  • Ensure optimal use of external resources against local RU project portfolio to ensure delivery of the portfolio
  • Provide some knowledge and advice through collaboration with the local Chemistry team; responsible for assessing business need for Chemistry Sourcing for the RU and delivering against those needs with the available resources
  • Work with RU chemistry LT to support changes in Chemistry outsourcing staffing paradigms to fully leverage external resources
  • Prime interface between CROs serving RU chemists; helping with chemistry issue resolution, IP protection, communication, IT tool support, data integration to and from the Pfizer systems
  • Ensure smooth processes are in place for outsourcing compound synthesis (project initiation, maintenance and wind-down)
  • Ensure optimal communication process/problem solving and win-win situation for external CRO to/from PFE
  • Ensure that vendor metrics are tracked and evaluated and adjusted by continuous improvement go be able to gain optimal ROI from our external chemistry collaboration
  • Work with digital, ERS members to ensure a smooth process for integration of compounds and data into Pfizer database
  • Liaise effectively with customers and stakeholders to ensure they have realistic expectations of the contracting process, external providers and the contracting environment and provide data and status information to enable enhanced resource utilization
  • Deliver appropriate training to customers / stakeholders (internal and external)
  • Support implementation of sourcing tools and processes at a local level to best support and improve outsourcing management and supplier management practices; ensure tools, process and systems are adequate to deliver specific Chemistry-focused needs.
  • Interfacing with vendors and project management with CRO chemists and project managers
  • Monitor vendor productivity with regular assessments
  • Provide input and support into global ERS group initiatives as appropriate.
  • Support RU-based chemists for logistical support regarding the management and oversight of external Chemistry resources (FTE, FFS, etc.) assigned for the RU.
  • Work with Synthesis leader to understand RU's portfolio needs (project, stages) and interface with the project team to help integrate chemistry sourcing for the RU
  • Participate in process improvement and harmonization of ERS Chemistry members through best practice sharing and process innovation.
  • Support a single or multiple RU chemistry sourcing management on all of the above.
  • May participate in working group/steering committee/affinity group for chemistry partners.
  • Support sourcing of physical chemical property measurements including logistic/data support and vendor management (work across RU if needed)
  • Be able to work collaboratively and effectively with other members of the ERS local and global groups ERS/Business and Research operations group/Biology ERS to ensure good cross communication/learnings and process optimization to serve the chemistry clients.
  • Learn the SMT sourcing support process.



  • Strong background in Synthetic or Medicinal Chemistry is required (PhD in Chemistry with 0-3 years of industrial experience or MS with 5+ years of industrial experience)
  • Synthesis or Medical Chemistry or Drug Discovery experience preferred
  • Demonstrated ability to work in a cross-matrix organization
  • Excellent interpersonal and leadership skills
  • Excellent verbal and written communication skills
  • Customer focused and solution oriented
  • Be able to handle different types of responsibilities and multi-task efficiently
  • Strong computer skills
  • Be adaptable to work in a multi-cultural environment
  • Have demonstrated application of continuous improvement


  • Experience as a chemistry lead/Synthesis POC/RPL in Med Chemistry
  • Understanding of the research and discovery process for SM/ADC projects
  • Experience managing Chemistry outsourcing and interacting with external vendors
  • Experience across multiple RU, either as a leader (preferred) or participant
  • Experience in compound management workflows
  • Experience with Chemistry sourcing, preferably analog prep, scale-up or parallel chemistry, analytical chemistry, structural biology sourcing

Relocation support available
Work Location Assignment:On Premise

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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