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Scientist - Chemical Biology

La Jolla, California
Closing date
Jun 18, 2024

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At Pfizer we deliver breakthroughs that change patients' lives. In La Jolla, we are dedicated to the development of oncology agents that disrupt cancer biology or redirect the immune system against cancer cells. The Chemoproteomics Team plays a vital role in this mission through enabling the discovery and molecular understanding of small-molecule therapeutics. We are seeking a researcher with strong cell and chemical biology laboratory experience.

As a Scientist in Chemoproteomics, your research will drive a deeper understanding of tumor biology by assessing target engagement, off-target profiling, protein interactomes, and investigation of drug mechanisms of action and resistance pathways. The successful candidate will participate on project teams, providing insight and technical expertise required for project progression. The individual will also work closely with the Medicinal Chemistry and Oncology Biology groups to innovate and develop the next-generation of therapies.

  • Prepare samples for chemical biology and proteomic studies
  • Develop and optimize protocols. Analyze and summarize results from western blot and mass spectrometry studies.
  • Participate on multi-disciplinary project teams, including developing experimental plans and communication of results
  • Learn and apply state-of-the-art chemical biology technologies for target engagement and interactome mapping.
  • Advance expertise and group technologies through participation in working groups, conferences, and training courses

  • B.S. degree with 6+ years' research experience in the fields of biology, biochemistry, or similar.
  • Experience with mammalian cell culture.
  • Experience with gel electrophoresis, western blotting WES, plate-based assays, IP, and/or protein quantification.
  • Excellent record keeping and attention to detail.
  • The ability to work in a fast-paced matrix-team environment.
  • Strong verbal, written communication, and interpersonal skills.

  • M.S. degree with 4+ years' research experience
  • Prior experience with chemical biology or proteomics approaches (e.g. click reactions, photoprobes, small-molecule interactomes, IP mass spectrometry, global proteomic profiling)
  • Contributions on scientific publications
  • Familiarity with drug discovery and oncology

Additional Information:
  • Eligible for Employee Referral
  • Work Location: On Site
  • Last Day to Apply: June 16, 2024

The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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