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Immunogenicity Principal Scientist

Andover, Massachusetts
Closing date
Jun 7, 2024

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Life Sciences, Immunology, Health Sciences, Drug Development
Position Type
Full Time
Job Type
Staff Scientist
Organization Type

Job Details

What You Will Achieve

The Immunogenicity Sciences Group within the Pharmacokinetics, Dynamics, and Metabolism (PDM) Department of Pfizer's Discovery and Early Development division is an industry-leading team whose mission is to identify key risks associated with unwanted clinical immunogenicity and influence drug design to mitigate those risks.

We are currently seeking an experienced immunogenicity scientist to join this highly innovative team and collaborate with key stakeholders across Pfizer's Research and Development, including Protein Engineering, Clinical Pharmacology, Drug Safety and Pharmaceutical Sciences. The Principal Scientist role will report to the Immunogenicity Sciences Lead and its core functions are the management of a team of lab-based scientists in their pivotal role in drug design and, drive the establishment of novel approaches to support immunogenicity risk assessment and mitigation strategies of Pfizer's diverse biologics portfolio.

This unique opportunity will immerse the successful candidate in a diverse array of biotherapeutics modalities being designed and developed to meet the needs of patients across Oncology, Inflammation and Immunology, Internal Medicine and Anti-infective disease areas. The successful candidate will drive advancement of our immunogenicity risk mitigation capabilities through scientific leadership, and application of fundamental immunology sciences to further improve the efficacy and safety of our biologics.

How You Will Achieve It
  • Design ad-hoc immunogenicity risk identification and mitigation strategies for Pfizer's biologic portfolio across all disease areas and modalities, oversee execution, data interpretation and delivery to stake holders
  • Closely collaborate with Pfizer's BioMedicine Design protein engineers and Research Units Team to enable the development of robust immunogenicity mitigation strategies in keeping with project objectives and timelines
  • Lead a team of scientists to execute de-risking strategies by applying in silico and in vitro tools to deliver high quality actionable data, navigate change of priorities, program accelerations and implementation of innovation
  • Identify talent development opportunities to support growth and career progression of team members
  • Safeguard diversity, equity and inclusion
  • Actively pursue innovation to improve assay suitability, quality, efficiency, and cost effectiveness
  • Identify gaps and investigate novel approaches or technologies to advance, improve or optimize scientific practices and procedures in immunogenicity risk assessment and mitigation
  • Represent the Immunogenicity Sciences group at Projects Teams meetings from discovery through early clinical development
  • Guide and support project Teams in the writing of Integrated Summary of Immunogenicity and other immunogenicity reports
  • Contributes to a change-agile, high performing culture of innovation, impact, trust, accountability, and mutual respect in a fast-paced matrix environment
  • Demonstrate our values and behaviors of Excellence, Courage, Equity and Joy.
  • Exemplify achievements through publications and external communications


  • PhD with +4 years of industry experience in drug discovery and development
  • MS with 9+ years of industry experience in drug discovery and development
  • Recognized expertise in immunogenicity risk assessment of biologics
  • Track record of scientific achievement in the field of immunology and immunogenicity
  • Understanding of perturbations of the immune system in diseases as diverse as cancer and auto-inflammation
  • Demonstrated success in team management, in particular lab-based scientists
  • Extensive practical experience of project liaison achieving results in a complex matrix environment
  • Proven track record in project management
  • Outstanding interpersonal and communication skills
  • Track record in publishing own work and through collaborations

Technical Skill Requirements
  • Core expertise & formal education in applied Immunology; displays significant knowledge of the fundamental relationships between innate and adaptive immunity with relevant diseases such as autoimmunity and oncology
  • Extensive understanding of clinical implications associated with unwanted immune cellular and humoral responses
  • Broad experience with state-of-the-art immunogenicity risk assessment tools and analytical platforms, with direct experience in assay design, execution, analysis, interpretation, and application to drug design
  • Solid familiarity with format, pharmacology, and immunogenicity of biologics
  • Significant knowledge of immunogenicity monitoring and mitigation
  • Collaborative skills and effective influencing/partnering skills in a complex, multi-discipline organization
  • Understanding of opportunities and challenges related to translation of in vitro and in silico models
  • Lead author or a co-author on internal/external publications and posters
  • Direct experience in interacting with external organizations, including academics and CROs

Behavioral Competencies
  • Outstanding interpersonal and communication skills.
  • High degree of self-awareness
  • Ability to excel in a collaborative, fast paced and dynamic environment.
  • Strong leadership in building and maintaining high performing culture of innovation, execution, impact, trust, change agility, accountability, and mutual respect withing the group and in all interactions outside the group
  • Strong adaptability to changing work assignments and priorities
  • Grows others; acknowledges contributions across the team
  • Able to identify opportunities for continuous improvements and lead implementation

  • Ability to work in a biological safety cabinet and perform complex data analysis

Work Location Assignment:On Premise

The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development


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