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Senior Associate Scientist (non-PhD), Cancer Epigenetics

La Jolla, California
Closing date
May 21, 2024

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Job Details


Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.


Pfizer's Oncology Research Unit (ORU) in La Jolla, California is seeking a Scientist focused on translating basic discoveries in the field of cancer epigenetics into novel therapeutics. To guide oncology discovery campaigns at Pfizer, the Scientist will utilize cutting-edge chemical and biological tools to support our pre-clinical drug discovery programs.

We are seeking an experienced cell and molecular biologist to contribute to the success of the Oncogenic Transcriptional Networks Group within the Cancer Cell Biology (CCB) Department. The candidate should have expertise in cell line engineering technologies, molecular and protein biology methods, and small molecule screening approaches preferentially in a drug discovery context. This is an exciting opportunity to apply cutting-edge methods and contribute to the target portfolios of the Oncology Research Unit of one of the world's leading developers of novel therapeutics.

  • Execute various cellular and molecular techniques to validate genetic or small molecule perturbations of targets and downstream pathways such as: western blot, qPCR, ELISA, MSD, immunoprecipitation, gene expression, luminescence-based assays, imaging platforms and flow cytometry
  • Carry out experiments to test the functional consequences of genetic (CRISPR-based gene editing technologies and RNA interference) and chemical perturbations in cell-based model systems
  • Develop cellular tools for advancing drug discovery projects including generation and maintenance of engineered cell lines in a wide array of established cancer types
  • Serve as a technical resource within the group for engineering and generating stable cell lines, genome-wide gene editing experiments, phenotypic and biomarker assay development, or other technologies
  • Design and conduct well controlled high-quality scientific experiments to test biological hypotheses
  • Assist with the evaluation of new approaches and technologies within the group
  • Maintain electronic lab notebook in compliance with company policies
  • Stay current with relevant technologies including those relating to molecular biology, cell biology, functional genomics and biochemistry
  • Work closely as a collaborative team member within Cancer Cell Biology and Oncology project teams

  • Bachelor's degree in cell and molecular biology or related field with at least 4+ years laboratory experience in an industrial or academic setting or master's degree with at least 2+ years laboratory experience, experience in oncology research is a plus

  • Expertise with an array of molecular biology methods including cloning, vector construction, PCR, DNA and RNA isolation, qPCR, and library construction
  • Expertise with a variety of cell biology techniques including cell culture, engineering and generation of stable cell lines, lentiviral production, gene expression analysis, protein expression analysis, and cell-based assays, phenotypic assays, biomarker assays, luminescence-based assays, reporter assays, imaging assays, and flow cytometric assays
  • Experience in CRISPR-based approaches or RNA interference technologies
  • Expertise in transcription factors, epigenetics or E3 ubiquitin ligase fields is a plus
  • Track record of successful contribution to research projects, preferably utilizing gene editing or screening methodologies
  • Ability to effectively interact and collaborate with other scientists, both within the group and in other groups; excellent communication and interpersonal skills

Work Location Assignment:On Premise

The annual base salary for this position ranges from $64,600.00 to $107,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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