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Director, Statistics (HEOR)

La Jolla, California, United States;Lake Forest, Illinois, United States;Canada - Quebec - Kirkland
Closing date
May 8, 2024

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Physical Sciences, Statistics
Position Type
Full Time
Job Type
Organization Type
All Industry, Pharma

Provide statistical leadership and technical support for Pfizer projects involving health economics and outcomes research (HEOR). This is a quantitative-based position with limited administrative responsibilities. The applicant will work with teams primarily in oncology and possibly in other therapeutic areas. The emphasis will be on sound statistical applications to patient-focused drug development and health technology assessment (HTA). The applicant is expected to develop highly effective collaborations with relevant stakeholders including those in Patient Health & Impact, the Patient-Centered Outcomes Assessment Group, Statistics, Clinical Pharmacology, Clinical Development, Medical Affairs, Epidemiology, Programming, and other groups contributing to HEOR analysis and strategy. The applicant is also expected to be highly proficient in HEOR methodology and strategy.

The primary responsibility and effort for the position is statistics-specific collaboration focusing on health economics and patient-reported outcomes and other clinical outcome assessments in oncology, inflammation & immunology, and other therapeutic areas. Responsibility extends to methodological research to improve the design, conduct, analysis, and interpretation of studies. In addition, given that the Statistical Research & Data Science Center, in which the position is housed, develops scientific collaborations to advance patient-centered development methodologies, the position may invite external publications and presentations (along with other professional activities).

The successful candidate will:
  • Collaborate in the development and post-approval environment through consultation and implementation of statistical techniques related to HEOR based on state-of-the-art research.
  • Enhance statistical expertise in value-based drug development among Pfizer HEOR scientists, statisticians, and clinicians through active engagement and leadership in research methodology and content-specific areas.

  • Provide expert statistical support to HEOR leads in the design, analysis, reporting, and interpretation of clinical outcome assessments (patient-reported, clinician-rated observer-rated, and performance-based outcomes) and health economics in HEOR projects involving clinical trials and observational studies, including those in development supporting drug approval and reimbursement, HTA, as well as other post-approval activities, in order to inform decision-making and also to guide medical strategy and the scientific narrative through publications and external presentations.
  • Partner with HEOR scientists, other HEOR statisticians, clinical statisticians, clinicians, statistical programmers, and others to develop and implement an effective plan to leverage HEOR data.
  • Participate in HEOR regular meetings as needed and engage in proactive communications with project leads to better understand scientific and business needs.
  • Provide computational and statistical advice on complex analytic issues supporting Pfizer's HEOR projects.
  • Develop, implement, and promote methodologies based on state-of-the-science computing and statistical research and dissemination of the results both internally and externally.
  • Provide a strong presence for Pfizer with HTA, regulatory and professional organizations to influence knowledge generation and content of regulatory guidelines to support the adaption of health economics and patient-reported and other clinical outcome assessments.
  • Develop effective collaborations with relevant non-statistical researchers.
  • Stay current with research on HEOR methodology and its applications pertinent to the Pfizer business needs.
  • Be up-to-date on training and compliance with all Pfizer SOPs as required based on the assigned curriculum.

  • Ph.D. in biostatistics or related discipline with 7+ years of experience with patient-reported outcomes, health economics, health technology assessment, and outcomes research methodology used in clinical trials and observational studies.
  • Displayed leadership experiences and capabilities including: the ability to influence and collaborate with diverse group of peers in a complex cross-functional environment, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

  • Candidates with less work experience, or experience in other fields, will also be considered if they have exceptional methodology research credentials and potential.
  • Experience with advanced knowledge of psychometrics, econometrics, and biometrics such as validation of health measurement scales, longitudinal data analysis, missing data methods, multiple comparisons techniques, cost-effectiveness analysis, generalized linear models, meta-analysis, real-world data analysis, and conjoint analysis.
  • Proficient with subject matter content in at least one therapeutic area like oncology or inflammation.
  • Experience with different phases of drug development, from Phase 2 to Phase 4, and the associated regulatory and reimbursement involved.
  • Evidence of creative thought-leadership, professional presence, and scholarship through publications and presentations.
  • Effective verbal and written communication skills in relating to colleagues and associates both inside and outside the organization.
  • Broad-based understanding of statistical theory and its application.

Work location: Site based/Hybrid


The annual base salary for this position ranges from $161,600.00 to $269,400.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 20.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.


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