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Senior Scientist - T Cell Biology (ADC Discovery and Cancer Immunology)

La Jolla, California
Closing date
May 8, 2024
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies that matter most. The ADC discovery and Cancer Immunology (ADCI) group in La Jolla, CA is focused on anti-tumor immunity and immune cell biology to support the execution and diversification of the Oncology Research pipeline and translate discoveries into novel therapeutics.

Our team takes a holistic approach to understand the interplay of tumor, stromal, and immune cells in the tumor microenvironment, striving to define the axes of intercellular communication that could be leveraged to generate novel therapeutics.

What You Will Achieve

As a Senior Scientist, you will be at the center of our operations and you will be a member of our growing Cancer Immunology team and contribute to our efforts in target validation, identifying and evaluating novel therapies in the field of Cancer Immunotherapy.

You will participate in pre-clinical drug discovery and development projects with a focus on Cancer Immunology. You will work in a fast-paced and highly collaborative team of motivated and scientifically rigorous scientists to conduct preclinical research and advance our pre-clinical drug programs. You will work as a key member of the T cell biology team, performing a range of in vitro and ex vivo studies that generate critical data for project teams.

You will be a technical and scientific expert in T cell biology responsible for conceptualizing, designing and executing cell-based functional assays, multi-parameter flow cytometry, target expression analysis, mechanistic, PD, biomarker studies, and accurate exporting, formatting, and presenting data for multidisciplinary project teams.

As a technical expert and scientific contributor with deep knowledge of T cell biology, you will be an active team member enabling decisions to drive projects forward. Your creativity in developing novel T cell-targeted immunotherapeutics will directly benefit an unmet need in patients.

How You Will Achieve It
  • Lead or co-lead biological drug-discovery programs, with an emphasis on clinical lead generation
  • Discover and develop new therapeutic modalities for cancer immunotherapy targeting T cells
  • Conduct bench work, keep up with relevant research field, and move drug development via interactions with cross-functional groups.
  • Conceptualize, design, and execute T cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, and biomarker identification
  • Execute mechanistic, PD, and biomarker studies for preclinical-stage therapies and ex vivo assays, including but not limited to multi-parameter flow cytometry, target expression analysis, and functional assays
  • Collaborate with protein engineering, translational pharmacology, PK/PD, toxicology, computational biology, and clinical development group to pursue the most promising drug candidates
  • Analyze and interpret data and share results with stakeholders
  • Record experimental protocols/results in detail and write technical reports for regulatory filings
  • Act as a resource for other scientists in the group


  • PhD degree with 2+ years or M.S. degree with 7+ years of experience in academia or industry
  • Strong knowledge in T cell biology with technical expertise in T cell-based functional assays (e.g. activation, differentiation, and proliferation), optimization of cell-based assays, experience ex vivo models to assess immune responses in human (and model animal species) whole blood, PBMCs, and various primary cell subsets
  • Hands-on experience using multi-color flow cytometry to immunophenotype murine and human cells from blood and tissues, measure analytes in serum, plasma, supernatant or cell lysates and cell culture techniques (e.g. spheroid cultures/3D assays) using MSD, Luminex or ELISA
  • Excellent organization and planning skills, the ability to work in a fast-paced environment independently and as part of a team, good verbal and written communication, and strong motivation with dedicated work ethics
  • Demonstrated proficiency in complex data analysis and excellent oral and written communication skills
  • Competent in independently designing, planning, executing, and interpreting experiments.
  • Proven capacity to manage an independent research program with minimal supervision.

  • Technical knowledge and experience in cancer immunology and the tumor microenvironment,
  • Experience in development of (multispecific) antibodies targeting T cells
  • Previous industrial experience with expertise in target validation and a track record of success in immune-oncology drug discovery.

  • Standing, sitting, bending, lifting, walking in a laboratory setting.
  • Use of Personal Protective Equipment (PPE) in a BSL-2 laboratory.
  • Standard business office conditions; sitting, standing as appropriate.


May require weekend work, as needed

There will be less than 5 % travel

Additional Information:
  • Relocation support available
  • Eligible Employee Referral
  • Work Location Assignment:On Premise
  • Last Day to Apply: May 1, 2024

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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