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Postdoctoral Fellow, Overcoming Acquired Resistance to RAS Targeted Therapies

La Jolla, California
Closing date
Apr 30, 2024

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Other, Other
Position Type
Full Time
Job Type
Postdoc Fellowship
Organization Type
All Industry, Pharma
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose where we translate science and technologies into the therapies and vaccines that matter most. Whether you are in discovery, ensuring drug safety and efficacy or supporting clinical trials, you will be a key contributor to our mission of bringing best in class medicines to patients around the world.

What You Will Achieve

Pfizer's Oncology Research Unit (ORU) is working to change the trajectory of cancer by translating breakthrough discoveries in cancer research into the best medicines imaginable for patients. Pfizer's ORU in La Jolla, California, is seeking a Postdoctoral candidate (PhD) forthe Oncogene & Cancer Vulnerabilities (O&CV) group within Pfizer's Cancer Cell Biology division. Pfizer's Cancer Cell Biology division is focused on applying the latest scientific knowledge and novel approaches to discover truly innovative therapies for patients. O&CV supports small molecule cancer drug discovery and development all the way from target discovery and validation through early clinical development. As a Postdoctoral fellow you will be an integral part of our collective efforts to discover and target drivers of tumor evolution to overcome acquired and adaptive resistance networks to existing small molecule therapies. You will work in a lab-based setting and carry-out molecular and cellular based assays including functional genomic studies and data analysis; employ critical thinking to design and interpret experiments and communicate research findings to mentors and the wider Cancer Cell Biology team. As the applicant integrates data from across different divisions they will gain exposure to the broad Pfizer organization, learn from collaborations with cross-functional teams and be part of a culture that embraces scientific excellence and personal development.

How You Will Achieve It

  • Design, execute and analyze experiments to address the basic and translational biology of novel drug targets, their molecular pathways, and their connection to human disease.
  • Design, execute and analyze experiments to interrogate adaptive and acquired resistance nodes and networks of small molecules targeting oncogenic signaling pathways to inform mitigation strategies for these tumor types.
  • Apply strong attention to detail in experimental design, execution, and interpretation.
  • Actively partake in scientific discussions and be informed of publications in relevant areas.
  • Effectively communicate and present research findings in small group meetings and larger project team meetings.
  • Take initiative to collaborate with colleagues within and across departments to drive projects forward.
  • Contribute to a culture that values teamwork, collegiality, accountability, and continued learning and growth.
  • Publish in high-impact journals.
  • Represent Pfizer at scientific conferences by presenting data resulting from independent research.
  • Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and cancer biology expertise.



  • PhD in T umor /Cancer Cell B iology, P harmacology, or similar. PhD students in the last year of their thesis work are eligible to apply if all other requirements will be met at the time of the position's start.
  • No more than 2 years of post-degree experience.
  • Strong record of scientific achievement: publications, conference presentations, etc.
  • Track record of independent research evidenced by at least one first-author publication in a peer-reviewed journal.
  • Track record of independent acclaimed research evidenced by conference presentation at internationally recognized conference series.
  • Strong proficiency with foundational Cell and Molecular Biology techniques (eg: Construct Design, Lentiviral Generation, Stable Cell line Generation, 2D-adhered and 3D-Spheroid Proliferation assays, Western blots, QPCR etc).
  • Strong proficiency in functional genomic and protein interrogation methods (eg: CRISPR, DTAG, etc). Experience in use of CRISPR-based techniques for gene knockout, gene editing.
  • Excellent organization and planning ability, good verbal and written communication skills, and strong intrinsic motivation to deliver breakthrough therapies for patients.
  • Willingness to make a minimum 2-year commitment.

  • Research experience in areas of tumor biology, such as tumor heterogeneity, plasticity, and adaptive networks/ acquired resistance to small molecule inhibitors.
  • Knowledgeable in oncogenic signaling pathways.
  • Proficiency in integration of molecular profiling data including transcriptomic, proteomic, and genomic datasets.
  • Experience using R-programing language for interpretation of large multi-omic data sets for figure generation.

Other Job Details:
  • Must have work authorization in the US
  • Work Location Assignment:On Premise. On Premise colleagues work in a Pfizer site because it's needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.

The annual base salary for this position ranges from $60,900.00 to $101,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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