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Principal Scientist - ADC Biology

Washington - Bothell, Washington
Closing date
Apr 19, 2024

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Life Sciences, Biology, Health Sciences, Drug Development
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
All Industry, Pharma

Job Details


At Pfizer we deliver breakthroughs that change patients' lives. The ADC Biology team plays a vital role in this mission through discovering and advancing novel ADCs while utilizing comprehensive biological evaluation of tumor associated antigens and linker payloads. To discover the next generation of therapeutics, we are seeking a highly collaborative scientific leader with expertise in cancer cell biology.


The successful candidate will be responsible for designing and executing preclinical discovery research activities in collaboration with cross functional project teams for drug development candidates. This individual will directly contribute to Pfizer Oncology pipeline and will be expected to drive collaborative efforts with cancer biologists, immunologists, chemists, and protein engineers to innovate and develop first-in-class oncology therapies. The successful candidate should have a record of being a strong scientist, team player, strategic thinker, and an effective communicator. This position will be responsible for directly mentoring and managing others including scientists and/or associates.


  • Design, conduct, interpret and document experiments utilizing a diverse array of techniques aimed at identifying and characterizing novel tumor associated antigens and evaluating novel antibody drug conjugates (ADC) payloads

  • Execute molecular and cell-based methodologies including flow cytometry, immunohistochemistry, cytotoxicity assays, reporter assays, ELISA, western blotting, WES and in vitro PD assays

  • Leverage cell surface target biology to guide therapeutic design and identify the appropriate preclinical models for therapeutic design validation

  • Design and execute comprehensive experimental plans that inform and enable project progression. Define clear go/no go criteria for projects in alignment with overall research and corporate strategy

  • Lead and/or co-lead project teams and serve as a subject matter expert in cancer biology. Stay abreast of relevant literature and act as an expert resource within research

  • Work independently and demonstrate the ability to collaboratively contribute to projects outside their own expertise

  • Present research results and methodologies at weekly meetings with immediate supervisor and/or project leader, project team meetings and other research forums.

  • Coach and mentor people for performance and scientific growth

  • Contribute to building a culture that embraces scientific excellence, urgency, continuous learning and improvement, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development



  • Ph.D. in Cancer Biology, Biological Sciences, Biochemistry, Engineering, Immunology or a related field

  • 5+ years of relevant postdoctoral and/or industry R&D/drug discovery experience

  • Expertise in oncology, cancer biology and cancer drug discovery

  • Ability to adapt and adjust to a rapidly evolving environment

  • Ability to identify and plan critical path experiments in alignment with team objectives

  • Uses critical thinking to solve complex problems, address challenges and overcome obstacles

  • Understanding of appropriate statistical design and analysis for pre-clinical experiments

  • Highly effective interpersonal skills, ability to identify and absorb critical information and convey it to relevant stakeholders

  • Strong written and verbal communication skills with the ability to communicate effectively to a wide range of audiences


  • 2-5 years of experience leading projects/programs in a biotechnology or pharmaceutical company focused on oncology discovery and drug development

  • Expertise in ADC discovery or cancer signaling is preferred

  • Prior experience managing scientists and associates

Relocation support available

Work Location Assignment:On Premise

The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development


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