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Senior Associate Scientist, Metabolism

Cambridge, Massachusetts
Closing date
Apr 18, 2024

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Health Sciences, Drug Development
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
All Industry, Pharma
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

Obesity is a growing health and economic burden worldwide. It is risk factor for other co-morbidities including heart disease, stroke, Type 2 Diabetes Mellitus (T2DM), certain types of cancer, and higher mortality risk from COVID-19 infection. The Internal Medicine Research Unit (IMRU) is seeking a highly motivated non-PhD scientist with in vivo and molecular biology experience to support preclinical drug discovery efforts around obesity. The ideal candidate will be able to design and execute experiments, as well as analyze, interpret, and effectively communicate results. The candidate will work closely with their manager and other IMRU Pfizer scientists to support exploratory and portfolio efforts.

How You Will Achieve It
  • Perform in vivo/ ex vivo/ in vitro experiments.
  • Conduct molecular biology experiments such as but not limited to transfection, gene expression analysis, immunostaining, ELISA and Western blotting.
  • Capable of following assay protocols and analyzing and interpreting data.
  • Compliance to laboratory safety and electronic notebook standards.
  • Work effectively with peers to support projects.
  • Identify and report any experimental problems, proactively troubleshoot causative factors, and implement necessary corrections following discussion with supervisor.


  • Bachelor's degree in biology, pharmacology, biochemistry, molecular biology or other related discipline
  • At least 3 years of lab experience in academia or in industry for Bachelor's.
  • Comfortable working with rodents (minimum: handling, dosing)
  • Familiarity with standard cell and molecular biology methods including but not limited to cell culture, siRNA and plasmid transfections, lentivirus preparation and transduction, immunoassays such as ELISAs and western blotting, and quantitative real-time PCR.
  • Ability to use appropriate software to perform data analysis.
  • Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, strong motivation with a dedicated work ethic.
  • Excellent verbal and written communication skills.
  • Creative, self-motivated and the ability to work independently including analysis and troubleshooting of experimental results and reviewing literature to formulate new approaches.

  • Experience with in vivo food intake/ body weight studies; or measurements of physical function (max force, treadmill running).
  • Knowledge of metabolism and pharmacology.
  • Experience working in or collaborating with industry.


Ability to work in vivarium with rodents

Work Location Assignment:On Premise

The annual base salary for this position ranges from $64,600.00 to $107,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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