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Senior Research Assistant - Cancer Biology (Lei Laboratory)

University of Texas MD Anderson Cancer Center
Houston, Texas
Closing date
Jun 11, 2024

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Health Sciences
Organization Type

Job Details

MD Anderson's Cancer Biology department has a long history of being a leader in the field of basic and translational cancer biology research. The department emphasizes the training of students, postdoctoral fellows and clinical fellows in the fundamentals of tumor biology to improve the outcomes of patients with malignancies. The department has built a program with close ties to many clinical departments to facilitate information exchange between the laboratory and the clinic. As such, faculty in the department are investigators on NIH funded collaborative cancer biology research grants. In addition, there are several physician-scientists who have joint appointments in Cancer Biology, facilitating the exchange of clinically-relevant information between the laboratory and the clinic.

The primary purpose of the Senior Research Assistant is to coordinate and conduct experiments in collaboration with a senior member of the laboratory. The candidate will facilitate the research compliance requirements of the laboratory and process routine reagent orders. Duties will include routine management of mouse colonies and perform genotyping for transgenic mice. Dr. Lei's laboratory is jointly supported by the Departments of Head and Neck Surgery and Cancer Biology.

We are interested in dissecting the oncogenic and metabolic pathways that dampen cancer immunogenicity. We will examine the molecular mechanism regulating the plasticity of myeloid cell response to immune stimulation and identify central factors regulating the tumor immune microenvironment. We integrate a rich repertoire of technologies, including biochemistry, flow cytometry, next-generation sequencing, single-cell immune profiling, spatial transcriptomics, and transgenic modeling, to vet the mechanisms underpinning innate immune tolerance of cancers.


Yu Leo Lei, DDS, PhD - Publications

  • Generally aid and support the PI in all their research and laboratory efforts.
  • Independently performing animal experiments in consultation with PI (breeding, weening, genotyping, bleeding, tissue harvesting, injections, downstream processing and analysis)
  • Performs animal maintenance (safety protocols and standards, record keeping of animal inventory).
  • Possess ability to train new members of the laboratory in animal techniques.
  • Standard molecular techniques and perform tissue culture.
  • Willingness to proactively learn new techniques and science.
  • Ordering reagents and supplies.
  • Other duties as required.


Required: Bachelor's degree in one of the natural sciences or related field.

Preferred: Master's degree in one of the natural sciences or related field.


Required: Three years of experience in scientific or experimental research work. With preferred degree, one year of required experience.

Preferred: Knowledge of Cancer Biology, Immunology, Metabolism, or Computational Biology.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.


The University of Texas MD Anderson Cancer Center in Houston is one of the world's most respected centers focused on cancer patient care, research, education and prevention. It was named the nation's No. 1 hospital for cancer care in U.S. News & World Report's 2023 rankings. It is one of the nation's original three comprehensive cancer centers designated by the National Cancer Institute.

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