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Lab Tian – Post-Doctoral Fellow (Computational Biology and Bioinformatics)

Wistar Institute
Philadelphia, Pennsylvania (US)
Commensurate with experience
Closing date
Apr 18, 2024

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Life Sciences, Bioinformatics, Computational Biology
Job Type
Organization Type
All Industry

Lab Tian – Post-Doctoral Fellow (Computational Biology and Bioinformatics)

The Wistar Institute has an opening for a motived candidate to join the Bin Tian lab as a Post-Doctoral Fellow to study regulation of mRNA processing and metabolism in cancer using computational and bioinformatic approaches. One area of our research is to examine how dysregulation of mRNA processing steps, especially the 3' end processing, impacts mRNA metabolism, such as subcellular localization and translation, and helps cancer cell survival and metastasis. A second area of our research is to examine therapeutic approaches that target vulnerabilities of cancer cells in mRNA processing and metabolism. The studies will involve transcriptomic analyses using various platforms, including long-read sequencing, single cell sequencing and spatial transcriptomics. Machine learning techniques will be heavily used for identification of determinant features that regulate mRNA processing and metabolism. Extensive collaborations with basic science and clinical science colleagues are expected. 


Candidates should have a Ph.D. degree in Computational Biology, Bioinformatics or a related field. Candidates who have experience in experimental biology and wish to advance a career in Bioinformatics and Computational Biology are also encouraged to apply. The successful candidate is expected to have good communication skills that are necessary for effective collaborations. Interested candidates should apply online as well as providing a CV including a summary of previous research and contact information of three referees to Dr. Bin Tian ( We offer a competitive salary and excellent benefits package.  


The Tian lab uses interdisciplinary approaches to study mRNA biogenesis and metabolism, with a special focus on the molecular mechanisms and cellular consequences of alternative cleavage and polyadenylation. We employ a variety of cutting-edge techniques spanning multiple fields, including molecular and cellular biology, computational biology and bioinformatics, and advanced imaging. Detailed research topics and publications can be found at .


The Wistar Institute is committed to diversity, equity and inclusion (DEI). All candidates must share our commitment to DEI. The Wistar Institute is especially interested in qualified candidates who can contribute, through their research, mentoring, and/or service, to the diversity and excellence of our academic/research community.


Located in the heart of the University of Pennsylvania Campus, in the University City area of Philadelphia, The Wistar Institute is a world leader in discovery science in the areas of cancer, immunology, and infectious disease. The Institute is committed to accelerating research from bench to bedside through distinctive approaches involving collaboration among scientific investigators as well as academic and industry partnership. Wistar’s dynamic intellectual environment, state-of-the-art facilities and streamlined administrative support empower advancement of brilliant science that changes the future of human health.


For more information about The Wistar Institute visit our website at


It is the policy of the Institute to provide equal employment opportunities to all individuals regardless of race, citizenship, ethnicity, color, creed, religion, marital status, national origin, ancestry, sex, age, veteran status, mental or physical disability (including HIV and AIDS), pregnancy, caregiver status, domestic or sexual violence victim status, sexual orientation, gender identity and expression, or on the basis of genetic information, or any other characteristic protected by federal, state, or local law, with respect to all terms and conditions of employment.





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