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Postdoctoral Fellows: Single Cell Multiomics and Cancer Genome Regulation

Cleveland Clinic, Lerner Research Institute
Cleveland, Ohio (US)
Commensurate with education and experience
Closing date
May 27, 2024

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Postdoctoral Fellows: Single Cell Multiomics and Cancer Genome Regulation

Two postdoctoral positions are available in Frank Xie lab at the Cleveland Clinic Lerner Research Institute (LRI) and Case Comprehensive Cancer Center. The postdoctoral fellows are expected to study two funded directions: (1) Single-cell multi-omics of the spatiotemporal regulation of development (Human Frontier Science Program); and (2) Genome regulatory mechanisms in cancer and immunity (NIH DP2).

The Xie lab is located in the historic city of Cleveland, Ohio, where the 100-year-old Cleveland Clinic is ranked as one of the top two national hospital systems.   Xie Lab develops unique tools and integrates super-resolution imaging, high-throughput sequencing, and genome engineering approaches to study fundamental regulatory mechanisms in development and disease (e.g., cancer).  Representative research articles include: Xie et al., Nature Methods, 2020; Xie et al, Nature Genetics, 2022; King*, Yost*, Xie* et al., Nature, 2021; Xie et al., Mol.Sys.Bio, 2021; Xie et al., Genes & Development, 2017; Knight, Xie et al., Science, 2015.  More details can be found at

The Xie lab has 4 postdoctoral fellows, 1 M.D./Ph.D. Student, and 1 research technician. We are building a multidisciplinary team of biologists, physicians, data scientists, tool builders, engineers, and others to study the frontiers of genome regulation in development, cancer, and immunity. We hope to apply our basic findings to translational medicine. We are recruiting two more enthusiastic and motivated postdoctoral researchers to study emerging questions about single cell biology and cancer genome regulation. Candidates should have a Ph.D. and/or M.D. degree with a proven track record of research publications (e.g., peer-reviewed first author articles) and excellent English communication skills. In this recruitment cycle, preference will be given to self-driven and detail-oriented candidates with prior solid experience in molecular and cell biology, synthetic biology, animal models, and/or computation.

Postdoctoral salaries are based on NIH standards and commensurate with past research experience. Excellent Cleveland Clinic’s insurance and benefit packages are included. Successful candidates will have access to Cleveland Clinic’s vast computational (e.g., IBM Quantum Computing), clinical, and medical resources and collaborate with physician scientists and clinicians to translate benchside research to bedside. Postdoctoral fellows will conduct mentored independent research, lead cutting-edge projects, gain solid research experience, and participate in guided collaborations, with the encouragement to develop unconventional ideas, risky projects, and cross-disciplinary frontiers. By the end of the training, postdoctoral candidates are anticipated to be equipped with top-tier journal publications, critical thinking, multidisciplinary mindsets, and excellent communication skills competitive for their next level of career advancement.

Interested individuals should directly email Dr. Liangqi (Frank) Xie at and with the title line as Xie_lab_Postdoc_Application

The postdoctoral fellow application material must include the following information.

1)  A cover letter describing prior research background, future research interests, career goals, and estimated start time.

2)  A CV, including publications and contact information for 3 referees.


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