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Staff Scientist - Immunology and Cancer Therapy Development

City of Hope
Duarte, CA
$34.96 - $118.63 / hour
Closing date
Feb 27, 2024

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Life Sciences, Immunology, Cancer Research
Position Type
Full Time
Organization Type

Job Details

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope , where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The Leo Wang Lab at City of Hope is hiring a staff scientist with expertise and interest in fundamental immune signaling to join our group in the Department of Immuno-oncology. We couple protein-focused molecular techniques (mass spectrometry, capillary Western blot, flow cytometry, CyTOF) with in vitro and in vivo disease models to define the molecular basis of chimeric antigen receptor (CAR) signaling and activation. We correlate these fundamental proteomic pathways with their functional consequences and use this information to aid in the rational design of solid-tumor targeted CAR constructs with improved persistence and potency. For more information on Dr. Leo Wang's research, please visit here .

As a successful candidate, you will:
  • Design and lead projects focused on CAR T cell signaling in multiple model systems, using canonical TCR signaling as a conceptual framework.
  • Coordinate lab tasks and operations among multiple lab members, including ordering, inventory, and other essential lab functions.
  • Keep detailed and accurate logs of experimental design and primary data, analysis, and synthesis.
  • Prepare data presentations and manuscripts for publication.
  • Initiate and maintain collaborations with other labs.
  • Travel to meetings to represent the lab and to present new data.

Your qualifications should include:
  • The Staff Scientist must possess, at a minimum, the U.S. equivalent Bachelor's or Master's degree in an appropriate discipline, and will often have a Ph.D. or other doctoral level degree.
  • Core competencies include cell and molecular biology, flow cytometry, protein biochemistry, and mouse work.
  • Extensive prior experience in immunology or a closely related field.
  • Preferred qualifications: Ph.D. or equivalent degree and 5 or more years of postdoctoral experience. Programming experience (R, Python).

City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity and inclusion, please click here .



City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research.  City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

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