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Senior Scientist - Metabolic Disease

Cambridge, Massachusetts
Closing date
Mar 4, 2024

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Health Sciences, Drug Development
Position Type
Full Time
Job Type
Senior Scientist
Organization Type
Role Summary

The key strategic focus area within the Internal Medicine Research Unit (IMRU) is identifying novel therapies to prevent or treat diseases associated with diabetes or the metabolic syndrome including NASH, obesity, renal disease and heart failure. Central to these metabolic diseases is adipose dysfunction whereby the normal physiologic function of adipocytes is impaired. In IMRU, our goal is to build a world class research team of dedicated scientists committed to developing a deep mechanistic understanding of metabolic disease pathogenesis. As a member of the discovery biology team, this individual will contribute to these efforts through the drug discovery process including ideation and hypothesis testing, identification and validation of therapeutic targets and disease related biomarkers. The successful candidate will collaborate effectively with a wide spectrum of scientific partners representing diverse disciplines and lead non-clinical studies. Knowledge and experience in the study of adipose metabolism is essential and familiarity with the pathophysiology of dysmetabolic states would be advantageous. In addition, the individual will build and facilitate collaborations with partners in the academic scientific community, as well as within the larger Pfizer network. She/he will have daily interactions with a team of creative and innovative scientists, working collaboratively in a supportive environment to conduct rigorous scientific and drug discovery research. Strong self-motivation, excellent communication and interpersonal skills, and the ability to both lead as well as work as part of a team are essential.


Successful candidates will be expected to:
  • Apply creative thinking and scientific expertise to the formulation of strategies to identify and validate therapeutic targets in key areas of interest to the Internal Medicine Research Unit.
  • Maintain an awareness of 'cutting edge' scientific and technical developments in preclinical to clinical translation and apply these where possible to advance the portfolio programs.
  • Conceptualize and design experiments.
  • Mentor junior scientists in developing skills essential to the execution of rigorous scientific research.
  • Organize and conduct in vivo/ ex vivo/ in vitro studies independently (including experimental design, data collection, interpretation, and presentation).
  • Quantify and translate experimental results to advance the understanding of how metabolic pathways and complex physiological systems are altered by diseases and how they respond to therapeutic interventions.
  • Build and facilitate collaborations with partners in the academic scientific community, as well as within the Pfizer network of scientists.
  • Present research findings to Pfizer colleagues and the scientific community through publication in peer-reviewed journals and talks and posters at scientific meetings.
  • Present and represent research programs to Pfizer leadership.
  • Ensure that all research/discovery work is conducted with highest quality and ethical guidelines and in accordance with relevant regulatory, QC, and compliance guidelines.

  • PhD with a minimum of 3 years of post-doc experience in metabolic diseases with a focus on adipose metabolism and physiology.
  • In vivo experience handling and maintaining rodent models of obesity is required.
  • Demonstrated ability to review critically available data and to think creatively in formulating novel hypotheses.
  • Successful record of scientific accomplishments as indicated by scientific publications and presentations.
  • Deep expertise in metabolism and/or signaling pathways.
  • Experience in performing in vitro, in vivo and ex vivo experiments.
  • The candidate should be able to work independently as well as with an interdisciplinary team of scientists in a highly collaborative environment.
  • Demonstrated ability to contribute to multiple projects in parallel with learning agility and scientific rigor.
  • Strong written/verbal communication skills and ability to collaborate effectively with scientists working in other disciplines.
  • Experience with CRISPR and molecule biology techniques is preferred.

Relocation support available

Work Location Assignment:On Premise

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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