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Scientist, Biotherapeutic Protein Purification and Conjugation

Cambridge, Massachusetts
Closing date
Feb 27, 2024

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Health Sciences, Drug Development
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
All Industry, Pharma

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.


Pfizer's BioMedicine Design (BMD) is seeking a highly motivated and experienced protein biochemist to join the high-energy and dynamic Biotherapeutic Expression and Purification group (BEP), which is responsible for generating non-GMP protein drug leads to support various Pfizer research units and their in-vitro and in-vivo needs in pre-clinical development. Qualified candidate will play an essential role in cross-functional team and will be responsible for processing of mammalian- and bacterial-expressed recombinant protein modalities including, but not limited to multispecific antibodies and conjugation of payloads to the antibodies, using state-of-the-art technologies and equipment. The candidate will contribute to the group-wide deliverables in highly collaborative environment and be required to work on several projects simultaneously presenting results and updates at group and project team meetings.

  • Support the development of scalable protein purification processes, and e nsure timely delivery of highly purified biotherapeutic candidates to discovery project teams
  • Assess quality of biotherapeutics rigorously and review all analytical documentation prior to protein release
  • Routinely provide updates at project meetings
  • Proactively evaluate new technologies and implement new features and functionality into discovery pipeline
  • Drive technology innovation. Maintain knowledge of scientific trends industry processes through readings, conferences and seminars; review literature to advance manufacturing procedures and methods
  • Will be involved in the design and execution of projects with the ability to operate independently
  • Work closely with multidisciplinary teams including therapeutic discovery teams, research units, bioanalytical teams, transient expression and stable cell line development groups, engineering leads, and R&D project leaders

  • MS with 3+ years or BS with 5+ years of relevant experience in Biochemistry, Biology, Biological Engineering or a related discipline along with a solid understanding of protein purification
  • Hands-on experience with protein purification (using affinity and traditional chromatographic techniques) on AKTA chromatography systems, including operating Unicorn and OpenLab CDS software packages.
  • Hands-on experience with protein conjugation
  • Hands-on experience with analytical biochemistry and experience in protein analytical characterization, including mass spectrometric analysis of protein
  • Able to work effectively in cross functional teams to solve process development problems or implement improved procedures
  • Strong written and verbal communication skills
  • Organized, detail oriented, multi-task, and remain flexible with changing needs
  • Must be self-motivated and able to work under strict timeline

  • Prior industry experience in antibody purification
  • Experience with DOE concepts and tools
  • Python and/or VB experience


Involves typical bioprocessing lab activities

Ability to routinely lift 50 lbs

Standing for prolonged periods of time, walking, bending, and using tools

Ability to perform mathematical calculations and ability to perform complex data analysis

Work Location Assignment:On Premise

The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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