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Postdoc Fellow / Senior Scientist

Employer
Harvard Institute of Medicine
Location
Boston, Massachusetts (US)
Salary
Commensurate with education and experience
Closing date
Mar 13, 2024

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Discipline
Life Sciences, Molecular Biology, Neuroscience
Job Type
Postdoc Fellowship
Organization Type
Academia

The Yakoub and Sulzer labs at Harvard Medical School-Brigham and Women’s Hospital and Columbia University are developing collaborative projects to explore transformative ideas focused on brain disease mechanisms and therapies and developing cutting-edge technologies for neuroscience. Example projects include:

1. Investigating the novel “virus/immune hypotheses” of neurodegenerative or neurodevelopmental diseases including Alzheimer’s, Parkinson’s and autism. Testing alternative hypotheses for the disease mechanisms, rather than the traditional hypothesis associated with therapeutic trials failures, is imperative nowadays. Moreover, the potential of viruses (e.g. SARS-CoV-2) to induce long-term neurological disorders over aging is now an important question due to the COVID-19 pandemic that exposed millions of people to virus.

2. Developing novel gene therapies to target neuronal cell biology processes such as autophagy or neural circuits that go awry in brain disease.   

3. Developing powerful technologies for gene editing in the brain or for neural circuit tracing or modulation that can be a strong complement/alternative to existing neuroscience technologies such as CRISPR, optogenetics, or deep brain stimulation.   

 

This is a fully funded multi-year position, to be jointly advised by Drs. Yakoub and Sulzer. The postdoc will receive the benefits of mentorship of both advisors, including training in both labs and career development support (e.g. grant writing and faculty job search/applications) from both advisors.   

 

The research requires broad skills in life sciences and neuroscience, including vector design and molecular biology, mouse skills and injections, behavioral analyses, calcium imaging, optogenetics, electrophysiology, histology, imaging, cell culture including iPSC-derived neurons and brain organoids, gene editing, and/or other relevant skills. Productivity, independence and motivation are necessary for success.

 

To inquire about this position, please send an email, with your CV attached, to ayakoub@bwh.harvard.edu and ds43@cumc.columbia.edu 

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