Salary £39,375 per annum
MRC Laboratory of Molecular Biology, Cambridge, UK
The assembly of TAR DNA-binding protein 43 (TDP-43) underlies multiple neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). We recently determined the cryo-EM structures of TDP-43 assemblies from the brains of individuals with ALS and FTLD, which revealed that TDP-43 assembles into amyloid filaments with distinct folds in different diseases (Arseni et al. 2022. Nature 601, 139-143; Arseni et al. 2023. Nature 620, 898-903).
This position is to develop and evaluate neuronal and mouse models that recapitulate disease-relevant TDP-43 amyloid filament structures. These models will enable the investigation of the molecular mechanisms of TDP-43 assembly and how they contribute to neurodegeneration.
We are looking for a scientist with a desire to work as part of a friendly and supportive team. Previous experience of neuronal cell biology and working with amyloids would be advantageous. They should contribute their expertise to the project, but will also be able to learn new approaches and to expand into new biological topics. The ideal candidate will have a PhD in a relevant subject, or be due to complete within 6 months.
We are looking for a Postdoctoral Scientist for our 3-year Career Development Fellowship/ Postdoctoral Training Scheme. This is a training and development position suitable for you if you have recently completed your doctoral studies, or you are looking to move into a new research discipline and/or need to further develop your research skills. Working with our world class scientists you will be working in an Institute renowned for its excellent scientific facilities and high-quality research.
The LMB has an inclusive and collaborative working culture and you’ll be based in our state-of-the-art building on the Cambridge Biomedical Campus. We have on-site parking, cycle enclosures and excellent public transport links to the site. You’ll be able to access our range of excellent benefits including a staff restaurant with roof terrace, on-site nursery, sports and social facilities. You’ll be eligible to join our defined benefit pension scheme with an employer contribution of 16%, holiday entitlement of 40.5 days per annum (including bank holidays and privilege days) and a generous employee discount scheme. We’re also committed to providing training and development opportunities including support towards role-related qualifications.
The MRC Laboratory of Molecular Biology (LMB) is part of UK Research and Innovation (UKRI) which brings together nine research and innovation partners, more information can be found at www.ukri.org and www.mrc-lmb.cam.ac.uk.
For informal enquiries please contact Dr Benjamin Ryskeldi-Falcon (firstname.lastname@example.org) or visit https://www2.mrc-lmb.cam.ac.uk/group-leaders/benjamin-falcon/ for more information.
This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply. Immigration costs (visa and health surcharge) can be reclaimed from UKRI after taking up the post (terms and conditions apply).
To apply and access full details of the vacancy please visit our job board at https://mrc.tal.net/vx/appcentre-ext/spa-1/candidate/post/5203/en-GB .
If you are unable to apply online please contact us at email@example.com.
Closing date: 07/01/2024
Final appointments will be subject to a pre-employment screening.
We actively support equality, diversity and inclusion. We therefore, particularly welcome women, minority ethnic and disabled candidates to apply for this vacancy as they are currently under-represented. We’re a disability inclusive employer and encourage disabled people to apply for this role.