The Science for Life Laboratory (SciLifeLab) is a national center for leading edge technological infrastructures that supports large-scale data and hypothesis-driven research in the field of molecular biosciences. SciLifeLab (www.scilifelab.se) operates nationally, engaging all major Universities of Sweden including the four founding universities: Karolinska Institutet, KTH Royal Institute of Technology, Stockholm University and Uppsala University. SciLifeLab brings together researchers across traditional boundaries and promotes collaborations with industry, healthcare, public research organizations and international partners. As a SciLifeLab Fellow, the recruited researcher will be part of the dynamic SciLifeLab community both locally in Uppsala and in Sweden at large. For information about the SciLifeLab fellow program, see https://www.scilifelab.se/research/#fellows. SciLifeLab Fellows are also part of a broad national network of future academic leaders within SciLifeLab and Wallenberg’s national program for data-driven life science (DDLS fellows) and the fellow programs at the Wallenberg Centers for Molecular Medicine (WCMM fellows), within the network Program for Academic leaders in Life Science, PALS, see https://www.palsnetwork.se.
SciLifeLab is currently looking for an excellent research group leader to reinforce the Uppsala research environment. The position will be within the Disciplinary Domain of Medicine and Pharmacy, with departmental affiliation decided in conjunction with the appointment.
Description of subject area
Advanced Therapy Medicinal Products (ATMP) are medicines with an active therapeutic substance based on genes, cells or tissues. Gene therapy is aimed at correcting genetic diseases or treat diseases by modifying or changing a gene or a gene fragment in the cells of a patient. Somatic cell therapy can include modifying cells or tissues to change their original function as part of the treatment. Tissue engineered medicinal products are cells or tissues that have been modified to repair, form or replace patient tissues. Adaptation to the make-up of an individual is a key aspect of ATMP, and the heterogeneity of a product (within a product batch or product characteristics, depends on the donor cells and varies between donors) can affect its efficiency and safety. Transport of cells from the patient to the laboratory and the laboratory environment can further complicate the production.
Standardization around how an ATNP is produced and characterized is under development. It is important to better understand how advanced pharmaceutical products are affected by various factors and thereby also optimize the treatment. This may include examining databases describing product development, including formulation strategies, and intra-product and inter-patient variability for different ATMPs. It also includes tissue/cell harvesting, laboratory handling, logistical development and immune-related side effects.
The position includes research in ATMP in one of the following areas: (1) development of new ATMP for the treatment of disease, (2) studies on how product quality, formulation and manufacturing, together with patient factors, affect the efficacy and toxicity of the final product, (3) ATMP studies with a focus on how the effectiveness and safety of these products contribute to prescribing and influencing the development of health economic models of value when introducing these new medicinal products.
Research, teaching and administration. Duties also include supervising doctoral students in their research projects and participating in first-cycle courses and study programmes at the department. The successful candidate will also be required to follow developments within the relevant fields of science, and any general societal development of significance to the interests of the University. Administrative tasks and internal and external elected office duties may arise. The position is intended to lead to the development of an independent research profile with national and international impact. The successful candidate is expected to strengthen the University’s contribution to SciLifeLab (www.scilifelab.se).