Postdoctoral –Oktay Laboratory Department of Obstetrics, Gynecology & Reproductive Sciences

Leading NIH-funded laboratory in ovarian biology, aging, and fertility preservation is looking for a postdoctoral candidate with strong background in ovarian and molecular biology. Firm knowledge in ovarian biology, and experience with single-cell qRT-PCR and RNA sequencing, epigenomics, bisulfite sequencing, microinjection and CRISPR techniques will be preferred. Interpersonal skills will be highly important as this is a multidisciplinary translational project. The Postdoctoral Associate will train and work on the role of DNA repair in oocyte aging as well as the relationship of BRCA and related mutations to reproductive and overall aging.

To understand the background of the Oktay laboratory’s theme, please refer to our recent publications:

1. Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans.Titus S, .. Oktay K. Sci Transl Med. 2013 Feb 13;5(172):172ra21.
2. Turan V… Oktay K. Association of Germline BRCA Pathogenic Variants With Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data. J Clin Oncol. 2021 Jun 20;39(18):2016-2024.
3. Titus S…Oktay K. Individual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve in vivo by triggering proapoptotic pathways without growth activation. Sci Rep. 2021 Jan 11;11(1):407.

Those who feel strongly qualified can email a cover letter and a CV to Colleen.Goble@Yale.edu, Associate Director of Academic & Administrative Affairs, Department of Obstetrics, Gynecology, and Reproductive Sciences. Only those with experience in reproductive biology should apply.