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Post Doctoral Fellow in Autoimmunity and Transplantation

University of Missouri, Columbia - Department of Child Health
University of Missouri, Columbia
Salary commensurate with experience: $50,000 - $70,000 per annum.
Closing date
Oct 13, 2023

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The Immunomodulation and Translational Research Program in the Department of Child Health, University of Missouri, Columbia, MO, is seeking 2 Postdoctoral Fellows to participate in federally-funded several projects developing immunomodulatory approaches with applications to transplantation (hematopoietic stem cells, pancreatic islets, and stem cell-derived beta cells), graft-versus-host diseases, and autoimmunity (with focus on Aplastic Anemia and Type 1 Diabetes). The program has developed various novel biologics and targeted delivery biomaterial platforms with demonstrated efficacy for immunomodulation in various settings (Immunity 2002; Nature Materials 2018; Biomaterials 2019; Science Advances 2020, 2022, Journal of Immunology 2020; American Journal of Transplantation 2023, Blood advances 2023).  Applicants must have extensive conceptual understanding and practical expertise in immunology, desirably rodent models of hematopoietic cell transplantation, GVHD, SC-derived beta cells, autoimmunity, or islet transplantation as well as strong microsurgical skills and hands-on expertise in immune cell functional assays.

Duties for Positions include:

  • Differentiate embryonic stem cells to insulin producing beta cells (SC-beta cells).
  • Allogeneic hematopoietic stem cell transplantation to establish mixed chimerism with application to prevention of allografts (islet, solid organs), and prevention and treatment of aplastic anemia and type 1 diabetes.
  • Perform immune cell functional assays, such as mixed lymphocytes reaction, deep immunophenotyping using flow cytometry, immunohistochemistry, qRT-PCR, and performing islet transplantation.
  • Participate in the generation and use of humanized mouse models to assess the efficacy of lead immunomodulatory protocols to prevent rejection of human islets or stem-cell-derived beta cells in humanized mice as preclude to clinical translation.
  • Design and execute experiments, data collection, analysis, and preparation for publications and presentations at national/international meetings.
  • Help in the day-to-day operation of the laboratory.
  • Perform other assigned duties on a needed basis.

Minimum Qualifications

  • Ph.D., M.D. or D.V.M. with a minimum of 3 years of basic laboratory experience and solid knowledge/experience in immunology.
  • Technical expertise in tissue culture, flow cytometry, and rodent handling and manipulations, such as injections, tissue collections, blood draw. 
  • Surgical skills with focus on pancreatic islet isolation and transplantation under kidney capsule or abdominal fat pad. Experience in solid organ transplantation is an added advantage.
  • Expertise in cellular immunology, including immune cell proliferation.

Interested candidates should send their CV to Dr. Esma S. Yolcu Haval Shirwan at

or or Apply at using job opening 47654.

For more information about our program, please log onto:

This position is eligible for University benefits.  The University offers a comprehensive benefits package, including medical, dental and vision plans, retirement, and educational fee discounts.  For additional information on University benefits, please visit the Faculty & Staff Benefits website at

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