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Associate Research Fellow- Hybrid Experimentalist/Computational Materials Scientist

Employer
Pfizer
Location
Groton, Connecticut
Salary
Competitive
Closing date
Jun 24, 2023
The Hybrid Computational/Experimental Materials Scientist serves as a scientific subject matter expert on multidisciplinary project teams working to bring new medicines to market. They are responsible for defining the final drug substance form (salt / polymorph / hydrate) for active pharmaceutical ingredients (API) and for defining the preferred physical attributes (particle shape / particle size / surface energy). They also lead the development of new scientific strategies within the group and mentor colleagues in the drug development process.

The position is based in Groton, CT (USA).

Responsibilities
  • Synthesize salt and co-crystal forms of drug candidates (including hydrates, solvates and polymorphs) and evaluate these forms for acceptability as drug substances as it relates to chemical manufacturing and formulation into pharmaceutical products. Develop innovative solid-state control strategies for development and commercialization.
  • Apply state-of-the-art computational approaches to predict the properties and performance of crystalline and amorphous drug substance samples.Use crystal structure prediction and solid-state informatics tools to de-risk the development of conventional and novel drug substances. Act as department resource for computational chemistry expertise.
  • Lead the solid-state characterization, selection, and optimization of small molecules of pharmaceutical relevance. This includes particle characterization (e.g., particle size, shape) and solid-state characterization (e.g., spectroscopy, X-ray powder diffraction, thermal analysis).
  • Oversee the work of external partners conducting laboratory and computational studies and provide technical guidance and critical analysis of data.
  • Apply technical knowledge to shape the strategic direction of external partnerships.
  • Represent the Materials Science group on multidisciplinary project teams and collaborate with colleagues to define and implement best-in-class screening and characterization strategies according to accelerated project timelines.
  • Draft and review sections of regulatory submissions (INDs, IMPDs, CTDs), patent applications, and peer-reviewed scientific publications.
  • Propose and lead the development of novel scientific approaches and the creation of new knowledge within the global Materials Science organization.
  • Mentor colleagues in the drug development process and ensure their professional growth so that they can lead projects of their own.
  • Recognized externally as an outstanding scientist. Influences the direction of external scientific research through academic research collaborations, external advisory boards, professional societies, and peer-to-peer networking.


Qualifications
  • A PhD in chemistry, engineering, materials science, or pharmaceutics (or equivalent subject) is required.
  • More than 10 years of relevant post-graduate experience (including post-doctoral studies) is desired.


Technical skills requirements
  • The candidate should have comprehensive experience in solid state characterization (such as x-ray powder diffraction, polarized light microscopy, differential scanning calorimetry, thermogravimetric analysis, NMR, etc) for crystalline, amorphous, and hydrated drug substances and drug-product intermediates.
  • Extensive experience of using contemporary computational approaches (such as Crystal Structure Prediction and Solid-State Informatics) to predict the properties and performance of pharmaceutical materials is required. A high degree of comfort with using computational modeling approaches is important.
  • A track record of solving complex solid state chemistry problems using experimental and computational techniques is needed.
  • Strong data analysis skills and in-depth knowledge of statistical concepts is expected.
  • In-depth understanding of the physical properties needed for drug substance manufacture and formulation into drug product is important.
  • An appreciation of current regulatory and intellectual property issues related to pharmaceutical materials science is desired.
  • A strong interest and motivation to explore and adopt new technologies and concepts is expected.
  • A track record pf presenting research externally thorough posters and peer reviewed publications is essential.
  • Good organizational skills, the ability to work independently, and excellent oral and written communication skills are required.


Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

PHYSICAL/MENTAL REQUIREMENTS

Ability to perform computational/mathematical calculations and complex data analysis.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Occasional travel to other Pfizer sites and conference venues may be required.

Additional Information-
  • Relocation support available
  • Eligible for employee referral
  • Work Location Assignment:On Premise
  • Last Day to Apply: June 23, 2023


Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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