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Postdoc positions in Alzheimer's disease research

Washington University School of Medicine in St Louis
Saint Louis, Missouri
Closing date
Aug 5, 2023

Postdoctoral Scientist – 2 positions

The Laboratory of Drs. Steven Paul and Anil Cashikar in the Departments of Psychiatry and Neurology, Washington University School of Medicine, is seeking applications for postdoctoral scientists interested in performing cutting edge research studying the basic mechanisms underlying neuroinflammation and neurodegeneration which characterize Alzheimer’s disease (AD) and related neurodegenerative disorders. Using in vitro and in vivo models, the Paul-Cashikar laboratory has recently discovered an important role for the immune-oxysterol 25-hydroxycholesterol (25HC) in mediating pro-inflammatory signaling by microglia to alter lipid metabolism in neighboring astrocytes and neurons, resulting in neurodegeneration. Our findings suggest important roles for innate and adaptive immunity in AD pathogenesis and support novel therapeutic strategies, also being pursued by the laboratory. We will have two new postdoctoral positions supported by a recently funded NIH grant to: (1) investigate the role of APOE and TREM2 signaling in 25HC-mediated neuroinflammation / neurodegeneration in AD mouse models and (2) develop iPSC-derived glia-neuron co-cultures to elaborate exactly how 25HC stimulates neuroinflammation and neurodegeneration.

Our lab is part of the Hope Center for Neurological Disorders which enables extensive collaborations. The postdoctoral scientists will have the opportunity to work with collaborators and develop an independent project. In addition to high-quality research facilities, career and professional development training for postdoctoral researchers is provided through the Career Center, Teaching Center, Office of Postdoctoral Affairs, and campus groups. Additional information on being a postdoc at Washington University in St. Louis can be found at .

REQUIRED QUALIFICATIONS: The ideal candidate will have a PhD in Cell Biology, Neuroscience or related fields with a track-record of publications demonstrating appropriate experience for each position – (1) mouse models, stereotactic injections, tissue processing, microscopy and image analysis; (2) iPSC models, CRISPR, drug screening. Successful candidates will work independently and exhibit curiosity-driven motivation to discovering new pathophysiological mechanisms of AD and to developing novel therapeutic strategies. Innovative thinking, prioritization skills, a strong work ethic, good communication skills, willingness to learn challenging new skills, and respect for co-workers are crucial attributes.

PRIMARY DUTIES AND RESPONSIBILITIES: The primary responsibility of the applicant will be to conceive, design, execute, and analyze studies. The applicant will lead in writing manuscripts and assist in preparing grant applications. Must maintain conformity with ethical standards in research and adhere to all applicable University policies, safety procedures, and regulations.

TO APPLY: Please submit the following as a single PDF file to – (1) a cover letter describing past research accomplishments, research interests, and career goals, (2) a current CV and (3) contact information for 3 references.

Washington University is a world-class research institution with a wealth of resources for conducting cutting-edge research. As part of the Hope Center for Neurological Disorders and the Taylor Family Institute for Innovative Psychiatric Research we are privileged to have extensive collaborations with top-tier labs as well as access to superb core facilities. The Washington University medical campus is also located along the eastern edge of Forest Park, which has earned a reputation as one of the country’s most beautiful city parks. St. Louis is a very friendly and livable city with a low cost of living. The metropolitan area has a diverse array of entertainment options including outdoor activities, dining, shopping, and an active sports scene (

EOE: Washington University is an Equal Opportunity Employer.  All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

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