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Senior Scientist, Protein Sciences

Groton, Connecticut
Closing date
Jul 1, 2023

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Health Sciences, Drug Development
Position Type
Full Time
Job Type
Senior Scientist
Organization Type
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Senior Scientist in the Cellular, Genomic, and Protein Sciences (CGPS) department, you will be at the center of our protein expression and purification operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be responsible for construct design and purification from bacterial, insect, and mammalian cells. With your deep knowledge of the discipline, you will be recognized as a technical expert and a scientific contributor who routinely partners with and mentors junior colleagues within the department and across therapeutic areas. Your innovation and creativity in developing novel processes and new ideas will be frequently used to drive decision making impact across the portfolio and establish a world-leading Protein Sciences pipeline to serve a world-leading Drug Discovery pipeline.

How You Will Achieve It

  • Represent Protein Sciences at the project team level, helping to guide new targets from gene to screen.
  • Troubleshoot scientific and technical challenges. Mentor more junior scientists to do the same.
  • Design constructs for expression in bacterial, insect, and mammalian cells to produce high quality recombinant proteins, protein complexes, and RNA.
  • Purify and characterize recombinant proteins to enable high throughput assays, biophysical assays, and structural efforts.
  • Prepare internally reviewed technical reports, make oral presentations to scientists and management, and publish externally.


  • Bachelor's Degree with 9+ years of experience OR Master's degree with 7+ years of Experience or PhD
  • Strong documented experience in protein biochemistry, protein purification, protein modification using enzymatic and chemical methods, and biophysical characterization.
  • Experience with antibody engineering in developing ImmunoTherapeutics.
  • Experience and knowledge in operation of modern mass spectrometry platforms and associated data analysis packages
  • Expert level knowledge of assay development methodologies for binding and functional activity
  • Ability to deliver results on goals in a fast-paced, dynamic and highly multi-tasking environment
  • Excellent written and oral communication skills


  • Experience with methods for successful purification of integral membrane proteins and nanoparticles (SMALP,, Nanodisc, etc)
  • Computational skills using Biacore, Octet, Microsoft Excel, and other applications designed to evaluate, process, and manage biosensor data
  • Protein engineering and/or thermal stabilization experience

  • Sitting, standing, lifting, bending, and walking.
  • Ability to perform practical laboratory bench work and work on a computer (while standing or sitting).
  • Ability to perform mathematical calculations and interpret data.

Other Job Details
  • Relocation support available.
  • Work Location Assignment:On Premise. Colleagues work in a Pfizer site because it's needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.

Last Day to Apply: August 1st, 2023

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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