Principal Scientst, In Vivo Pharmacology CVM-Surgeon Echocardiographer

Job Description

$9.0 billion R&D spend to develop breakthrough medicines! We are seeking a highly motivated scientist to join our in vivo pharmacology team in the Cardiovascular and Metabolic (CVM) Disease Area at the Novartis Institutes for BioMedical Research (NIBR) located in Cambridge, MA. Cardiometabolic disease is the leading cause of death worldwide, taking an estimated 17.9 million lives each year. Our team is dedicated to the creation and development of innovative medicines to change this alarming statistic. We conceive, develop, validate, and employ pharmacological tools to evaluate the efficacy and safety of novel cardiometabolic drug candidates.

As an experienced and skilled lab-based surgeon and echocardiographer, you will work both independently and collaboratively in an inter-disciplinary setting to execute experiments in preclinical models of cardiovascular disease. You will generate rodent dietary or surgical models of cardiac dysfunction/heart failure, perform invasive hemodynamic assessments, and conduct multi-mode echocardiography including strain by speckle tracking and Doppler imaging. You will collect, analyze, interpret data and report cardiac structural and functional data in both written study reports and in team meetings. You will support drug discovery for heart failure and arrhythmia therapeutics, while broadening your knowledge in the field.

What you will be doing (key responsibilities):
• Independently generate rodent dietary or surgical models of cardiac dysfunction and heart failure.
• Conduct invasive hemodynamic assessments (PV loop) in said models
• Design, execute, analyze and document in vivo echocardiographic experiments in heart failure and/or arrhythmia models.
• Function as lead pharmacologist on drug discovery projects as appropriate.
• Establish new imaging techniques and approaches to support heart failure or arrhythmia studies
• Support drug discovery projects with pharmacokinetic/pharmacodynamic (PK/PD) studies
• Present results in lab and department meetings
• Assist in the completion of research reports to support regulatory filings

The pay range for this position at commencement of employment is expected to be between $107,200 and $160,800/year; however, while salary ranges are effective from 1/1/23 through 12/31/23, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you will bring to the role:
• MS, DVM or recently completed PhD in pharmacology, physiology, or other life sciences area. Professional degree in veterinary sciences is a plus.
• Experience in generating and studying rodent models of cardiac dysfunction and heart failure. Proficiency in experimental microsurgical procedures is essential.
• Experience in rodent echocardiography. Knowledge and experience in non-human primate echocardiography is desirable.
• Experience in handling, dosing, and phenotyping animal models of disease, ideally with an emphasis in heart failure, arrhythmia or cardiorenal disease, experience with non-rodent models would be a bonus
• Proven expertise in PK/PD and efficacy experimental design and execution
• Expertise with ex vivo mechanistic models is desirable
• Experience in working with a multidisciplinary team of scientists
• Basic knowledge of statistics and experience with common statistical software for biomedical research
• Proficiency with Microsoft Office (Word, Excel, and PowerPoint)
• Strong written, oral and record keeping skills

Our Expectations:
• An ability to work both independently and as part of a team
• Flexibility and aptitude for learning, with a passion to drive groundbreaking science

Here you will:
• Join a team committed to bringing more of our medicines to more people, no matter where they are
• Work with the latest technologies
• Work with industry innovators on a regular basis

Why Novartis?
236 million lives were touched by Novartis Innovative Medicines in 2022, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could achieve here at Novartis!

Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network