Senior Scientist, Proteomics Chemical Biology

Cambridge, Massachusetts
Closing date
Jun 14, 2023

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Senior Scientist in Chemical Biology Proteomics

Pfizer, Kendall Square, Cambridge MA

Would you like to discover the medicines of the future?

At Pfizer we deliver Breakthroughs That Change Patients Lives .

In the Chemical Biology group, we play a vital role in this mission as key partners in the discovery of Pfizer's small molecule and synthetically-derived drugs. We are seeking scientific innovators with expertise in chemical biology, particularly focused on mass spectrometry-based proteomics.

Discovering new medicines at Pfizer takes teams with a diversity of skills, behaviors and approaches. Creativity, scientific excellence, tenacity, passion, hard work, organization, teamwork, courage, open-mindedness, and curiosity are the fabric of our team. We are looking for an ambitious Chemical Biologist, eager to see their work lead to important new medicines and scientific breakthroughs, to join our team.

As a Senior Scientist in the Chemical Biology group your work will drive a deeper understanding of the mechanism of action of our molecules and cellular targets. Relevant methodologies include, but are not limited to protein-protein and protein-small molecule interactomes, identification of novel targets, small molecule target deconvolution, small molecule target occupancy studies using chemical probes.

Role Responsibilities
  • Develop innovative chemical biology methods, with an emphasis on quantitative protein mass spectrometry technologies.
  • Enable new small molecule projects in the portfolio, through collaborations with disease area biologists and chemists.
  • Present and report data with follow up discussions for project teams including data impact and interpretation.
  • Enhance the external reputation of Pfizer's Chemical Biology capabilities through publications and presentations at leading conferences
  • Drive innovation in all aspects of laboratory operations including sample preparation, running mass spectrometers, data analysis and interpretation.
  • Work with local leadership to put in place an active program of self-development in chemical biology skills

  • PHD degree in mass spectrometry-based proteomics/biochemistry/chemistry or related field with experience in chemical biology/chemo-proteomics.
  • Operate high-resolution LC-MS instruments (Thermo: QE-HF, Lumos, Exploris 480, Bruker: TimsTOF ) and ensure high-quality data.
  • Experience with quantitative proteomics data analysis, including Proteome Discoverer, MaxQuant, or equivalent analysis platforms is required. Some programming expertise is a plus.
  • Experience in affinity based mass spectrometry and proximity labeling methodology preferred.
  • Proficiency in protein biochemistry techniques (examples may include subcellular fractionation, western blot, in-gel fluorescence) is preferred.
  • Familiarity with biorthogonal chemistry, site-selective protein modification, photo affinity cross-linking, activity-based protein profiling (ABPP) is a plus.
  • Exceptional documentation and communication skills.
  • Self-motivated and highly effective in a team-based environment.
  • Examples of peer-reviewed publications from scientific work to date.

Additional Information:
  • Relocation support available
  • Eligible for Employee Referral
  • Work Location Assignment:On Premise
  • Last Day to Apply: June 17, 2023

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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