We are interested in delivering mRNAs of interest to express proteins which drive cellular reprogramming. Specifically, we want to deliver mRNAs which drive hepatocyte expression of either (a) a protein made by the hepatocytes, is secreted systemically and acts in lung myofibroblasts to attenuate fibrosis or (b) and intracellular protein, synthesized by diseased hepatocytes which reprograms the hepatocyte to a healthy phenotype. The post-doctoral candidate will utilize in vitro and in vivo models, developed at CTI-San Francisco (CTI-SF), to mechanistically determine mechanisms associated with cellular reprograming of cell state. The candidate will work closely, but independently, with the relevant portfolio program teams at CTI-SSF. ROLE RESPONSIBILITIES
- Demonstrate deep scientific and technical expertise harnessed to advance our understanding in the fields of immunology, inflammation, oncology, rare disease, mRNA and/or gene editing, produce high-impact publications, present at conferences and ultimately contribute to the delivery of novel, life-changing therapies for patients.
- Independently design and test biological hypotheses, while also leveraging the breadth of expertise available from other Postdoctoral Fellows and subject matter
- experts across Pfizer and the external academic collaborative network.
- Execute targeted in vitro and in vivo experiments, while leveraging state of the art technologies and resources to address fundamental questions regarding cancer drug resistance mechanisms that can uncover novel therapeutic angles in this space.
- Generate, organize, analyze, interpret data, and identify areas where key knowledge is lacking. Proactively seek new scientific leads via genetics & AI-based resources, literature, conferences and key opinion leaders with the goal of refining scientific hypothesis and expediting experimental plans.
- Effectively communicate results at internal and external events and proactively contribute to the continued scientific growth at Pfizer.
- Contribute to a culture that embraces scientific excellence, effectiveness, and team-work.
- Recent Ph.D. in molecular and cell biology, rare disease, cancer biology, immuno-oncology, immunology, or a related field, with a strong track record of scientific publications.
- Significant expertise with an array of molecular and cell biological techniques, including genome editing and insertion methods, QPCR/Nanostring, mRNA IVT, transfection protocols, primary cell tissue culture and assays (human PBMCs, etc), multi-color flow cytometry, bioinformatics analysis and/ or in vivo models for oncology and other therapeutic areas.
- Must have excellent organizational and planning skills, and the motivation and ability to work in a fast-paced environment independently and as part of a team.
- Excellent verbal and written communication skills. Ability to quickly master new concepts and techniques.
OTHER JOB DETAILS
- Direct experience with mRNA delivery, gene editing, gene insertion, transcriptional regulation of cell programs, innate immunity and /or cancer biology
Must have Work Authorization in the United States.
The annual base salary for this position ranges from $59,200.00 to $98,600.00. In addition, this position offers an annual bonus with a target of 7.5% of the base salary. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans. Salary range does not apply to the Tampa, FL location.
Relocation assistance may be available based on business needs and/or eligibility.Sunshine Act
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Research and Development