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Staff Scientist - Immunology and Cancer Therapy Development

Employer
City of Hope
Location
Duarte, CA
Salary
$34.96 - $118.63 / hour
Closing date
Nov 2, 2023

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Discipline
Life Sciences, Immunology, Cancer Research
Position Type
Full Time
Organization Type
Healthcare/Hospital

Job Details

About City of Hope

City of Hope's mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913, City of Hope has grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis for numerous breakthrough cancer medicines , as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center at its core, City of Hope brings a uniquely integrated model to patients spanning cancer care, research and development, academics and training, and innovation initiatives. City of Hope's growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, andtreatment facilities in Atlanta, Chicago and Phoenix. City of Hope's affiliated group of organizations includes Translational Genomics Research Institute and AccessHope TM . For more information about City of Hope, follow us on Facebook , Twitter , YouTube , Instagram and LinkedIn .

City of Hope's commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

The Leo Wang Lab at City of Hope is hiring a staff scientist with expertise and interest in fundamental immune signaling to join our group in the Department of Immuno-oncology. We couple protein-focused molecular techniques (mass spectrometry, capillary Western blot, flow cytometry, CyTOF) with in vitro and in vivo disease models to define the molecular basis of chimeric antigen receptor (CAR) signaling and activation. We correlate these fundamental proteomic pathways with their functional consequences and use this information to aid in the rational design of solid-tumor targeted CAR constructs with improved persistence and potency.

Key Responsibilities include:
  • Design and lead projects focused on CAR T cell signaling in multiple model systems, using canonical TCR signaling as a conceptual framework.
  • Coordinate lab tasks and operations among multiple lab members, including ordering, inventory, and other essential lab functions.
  • Keep detailed and accurate logs of experimental design and primary data, analysis, and synthesis.
  • Prepare data presentations and manuscripts for publication.
  • Initiate and maintain collaborations with other labs.
  • Travel to meetings to represent the lab and to present new data.


Basic education, experience and skills required for consideration:
  • The Staff Scientist must possess, at a minimum, the U.S. equivalent Bachelor's or Master's degree in an appropriate discipline, and will often have a Ph.D. or other doctoral level degree.
  • Core competencies include cell and molecular biology, flow cytometry, protein biochemistry, and mouse work.
  • Must be able to generate data quickly and carefully, synthesize it to design new experiments, and communicate findings efficiently in manuscript form.
  • Must be able to design and execute scientific projects independently.
  • Ability to develop cohesive team relationships and manage teams.
  • Extensive prior experience in immunology or a closely related field.
  • Good English oral and written communication skills; must be able to prepare scientific manuscripts.
  • Ability to respond effectively to constructive feedback.

Preferred education, experience and skills:
  • Ph.D. or equivalent degree and 5 or more years of postdoctoral experience.
  • Programming experience (R, Python), preferred.

Additional Information:
  • For more information on Dr. Leo Wang's research, please visit here .
  • The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate's experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.
  • As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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Company

City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research.  City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

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