Senior Associate Scientist - Toxicology

Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

ROLE SUMMARY

We are seeking a highly motivated laboratory scientist to join Pfizer Global Research and Development laboratories based in Groton, CT. The Scientist position is in the Genetic Toxicology department within Global DSRD Discovery, Investigative and Translational Sciences (G-DITS). The scientist will work as part of a team to conduct both in vitro and in vivo genetic toxicology studies in support of drug discovery and development. The primary responsibilities of the position are to conduct the Ames bacterial mutation assay (multiple platforms), conduct DNA sequencing as part of a larger duplex sequencing assay development project, and be involved with hands on in vivo work for the Big Blue Mutation assay as well as In Vivo MN. Additionally, the role will include training in the in vivo comet assay, both GLP and Non-GLP. Commitment to scientific understanding of the data and development of technical expertise are required. The successful candidate will have experience working in a cellular biology laboratory, in particular using bacterial cells, as well as experience with in vivo genetic toxicology and demonstrate the ability to thrive in a fast-paced environment and involvement in multiple assays weekly.

What You Will Achieve

As a Senior Associate Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. Pfizer's Clinical Pathology laboratory is a highly innovative, functional and integrated scientific discipline contributing to the advancement of the overall portfolio. You will provide laboratory support for the Global Clinical Pathology laboratory including routine Clinical Pathology and investigative biomarker support for the efficacy and safety evaluation of drug candidates in discovery, pre-clinical, and clinical studies. You will also support routine clinical pathology analysis, involving hematology, clinical chemistry, coagulation, immunoassay and urinalysis.

Your significant experience of applying knowledge of principles, concepts, and practices of the discipline will make you a critical member of the team. Your skill and knowledge will help in making decisions that require choosing among limited options. You are proactive in contributing to all team discussions and creating an environment of collaboration.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

• Contribute to achievement of immediate work group goals and collaborate with other team members.
• Participate in scientific and technical review of the written study protocol.
• Conduct data analysis to generate data tables and graphs in partnership with the Study Toxicologist, Study Pathologist and/or Service Desk and identify trends or other study observations potentially affecting the integrity or quality of the study.
• Oversee and/or complete quality control review of in-life data for accuracy and completeness against the protocol and applicable Standard Operating Procedures.
• Design and perform in vitro experiments to address key mechanistic and pharmacological scientific questions.
• Author Pristima protocols based on the written protocol and ensure integrations with Cerner and send requirements are maintained.
• Serve as a Subject Matter Expert with respect to overall requirements and functionality of the Pristima system.
• Serve as a working supervisor/team leader and oversee completion of the daily technical activities and work of a group of colleagues responsible for the in-life phase of animal safety studies.
• Independently identify, summarize and troubleshoot issues that arise during toxicology studies.
• Responsible for fit-for-purpose assay development and must have the ability to effectively balance assay rigor against study goals and ensure timely delivery of high-quality biomarker data.
• Serve as a primary contact representing Study Conduct in cross-functional scheduling and resourcing activities providing expertise to appropriately manage in vivo staff resourcing.

ROLE RESPONSIBILITIES

• Attention to detail and conduct of established protocols using aseptic techniques
• Willingness to conduct in vivo work including harvest of organs for ex-vivo analysis
• Generating high quality data in a timely manner, review and upload of data into databases and data QC
• Close collaborations and effective communication with peers and leaders
• Willingness to work on a team

Qualifications

BASIC QUALIFICATIONS

• MS in Biology or related field
• BS in Biology with more than 3 years relevant experience
• At least 1 year experience working in a biology laboratory
• Mastery of cell culture and molecular techniques
• Responds well to scientific challenges and applies significant rigor to their own work
• Self-aware; will seek input from others on ideas and problem-solving; uses others as a resource
• Change agile, capable of quickly adapting to changes in project direction, role assignments, reporting relationships and department organization.

PREFERRED QUALIFICATIONS

• At least 1 year experience conducting the bacterial reverse mutation assay
• Familiarity or experience in next-generation sequencing (sequencing library preparation and data analysis)
• Experience conducting in vivo work including rodent organ harvesting and comet slide electrophoresis

Work Location Assignment:On Premise

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Relocation assistance may be available based on business needs and/or eligibility.

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development