Biomedical research - postdoctoral

Postdoctoral fellow/scholar position is available immediately in a multidisciplinary team studying molecular and cellular mechanisms of Alzheimer’s disease and cancer with the goal of developing therapies and diagnostics.

This opportunity offers the candidate to leverage skills in cell biology, molecular biology or chemical biology with cutting-edge biomedical research in cancer and Alzheimer’s disease. The successful candidate must be proficient in and willing to learn state-of-the-art concepts and techniques in biomedical research, communicate effectively with collaborators, and thrive in a highly collaborative team environment.

The position will involve the study of molecular and cellular mechanisms of disease through the application of best-practice cell and molecular biology techniques combined with systems-level analyses. The position will require a highly motivated scientist who can work on interdisciplinary projects of translational significance. The individual will collaborate very closely with biomedical researchers, chemical biologists, computational chemists and bioinfomaticians from New York University Grossman School of Medicine, Nathan Kline Institute, and Columbia University, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain to work on joint initiatives.

For publications relevant to this research please refer to:

• Nature Reviews Cancer 2018 Sep;18(9):562-575. Adapting to stress - chaperome networks in cancer.
• J Neurochem. 2021 Dec;159(6):958-979. The penalty of stress—Epichaperomes negatively reshaping the brain in neurodegenerative disorders.
• Nature 2016 Oct 20;538(7625):397-401. The epichaperome is an integrated chaperome network that facilitates tumour survival.
• Nature Communications 2020 Jan 16;11(1):319. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.
• Nature Communications 2018 Oct 19;9(1):4345. HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.
• FEBS Journal 2022 Apr;289(8):2047-2066. Disease-specific interactome alterations via epichaperomics: the case for Alzheimer's disease.
• Commun Biol. 2021 Nov 25;4(1):1333. Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer.
• Trends Pharmacol Sci 2023 Jan;44(1):20-33. Targeting stressor-induced dysfunctions in protein-protein interaction networks via epichaperomes.

The successful candidate will preferably:

• be a highly motivated researcher with relevant research background
• be interested in contributing to cutting-edge research
• be self-motivated and a pro-active thinker
• have demonstrated ability to work independently and lead projects while also collaborating and assisting the group achieve its research goals
• have knowledge in or prior experience in working with cell and mouse models of disease

Requirements:

• Ph.D. in Life Sciences
• Creativity in problem solving and a team spirit
• Good communication/written skills
• Passion for science.
• Ability to work towards defined goals in an efficient, safe and scientifically sound manner.

Candidates with an ability to interact well with a large interdisciplinary team are encouraged to apply.

Job Type: Full-time

Salary: $60,000.00 - $80,000.00 per year

Choosing MSK for your postdoc is a wise investment in your future. Among the benefits of training with us are:

• Excellent job prospects
• World-class science 
• A vibrant city and community
• Career and professional development  
• Housing and childcare
• Competitive compensation and benefits

https://www.mskcc.org/education-training/postdoctoral/why-choose-msk

Schedule:

• Self-determined schedule; Work Location: in New York, NY 10065

Written applications, including a cover letter, CV and contact details of three professional referees should be forwarded to coratio2712 at yahoo.com and chiosisg at gmail.com.

The applicant will be hired as part of the Chiosis lab at Memorial Sloan Kettering. For more information on Memorial Sloan Kettering Cancer Center and the Chiosis lab see www.mskcc.org and www.mskcc.org/chiosis

Memorial Sloan Kettering Cancer Center is located in New York City, in Manhattan’s Upper East Side, adjacent to the Cornell University Weill Medical College and the Rockefeller University, and a cab drive away from New York University Grossman School of Medicine, Nathan Kline Institute, and Columbia University, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain. This rich scientific environment provides many unique and unparalleled research training opportunities (www.mskcc.org/education-training/postdoctoral)