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Data Science - Bioinformatics Intern

Spark Therapeutics
Philadelphia, Pennsylvania. Hybrid and remote options available for select opportunities.
Salary not provided
Closing date
Apr 4, 2023

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Job Details

The Computational Biology & Machine Learning Group within the Genomics & Data Science Organization at Spark Therapeutics is seeking an engaged and passionate Data Science Intern with a focus on bioinformatics and computational biology to participate in and support projects involving omics and other high-dimensional data across the Research & Technology Organization. Working with the senior colleagues in the group, he/she will be responsible for:

  • Analysis and interpretation of high-dimensional data, including genomic, transcriptomic, and proteomic datasets
  • Developing and maintaining custom bioinformatics tools, e.g., Shiny apps to analyze and visualize internal and external data for the Spark research community
  • Engaging in cross-functional discussions, providing conceptual input in experimental and study design, and serving as subject matter expert in bioinformatics
  • Summarizing, visualizing, and presenting analyses and findings to key stakeholders Work with Bioinformatics team and broader Spark scientists to gather requirements for capabilities, i.e. workflows and/or application endpoints
  • Validate and document all builds and utilize reproducible workflows


% of Time

Job Function and Description


Develop capabilities - workflows and/or application


Work with Data Science, Bioinformatics, and research scientists to gather requirements


Trainings, meetings, and administration work

Education and Experience Requirements

  • BS/MS in Computer science, Computational Biology, Bioinformatics, or related disciplines
  • Experience with NGS tools (BWA, Samtools, fastqc), data science tools and languages (R/Python), and the linux operating system
  • Experience with R Shiny and application development
  • Demonstrable track record in the core competency areas: Scripting/programming, plotting and visualization, NGS workflows

Key Skills, Abilities, and Competencies

  • Working knowledge of one or more common data science languages such as Python, R, SPARQL, SQL
  • Experience with R Studio/Posit ecosystem tools such as Shiny, tidyverse, and Connect
  • Background and skills in building light apps (Shiny/Flask/Django) etc.. for visualization and analyses
  • Familiarity using bioinformatics workflow technologies such as SnakeMake, NextFlow, Docker
  • Strong familiarity with core concepts in molecular biology and related lab technologies
  • Track record of following best practices of coding, version control (Git), code documentation, and reproducible research
  • Proven ability to work independently & in a collaborative group setting
  • Self-motivated to learn and develop new methodologies, manage multiple analysis pipelines simultaneously, keep accurate records, follow instructions, and comply with company policies.
  • Excellent communication skills (both oral and written)

Complexity and Problem Solving

  • Develops solutions to a variety of complex problems
  • May refer to established procedures and policies
  • Work is performed under general direction and guidance where needed
  • Participates in establishing objectives of assignments and projects
  • Work is reviewed upon completion for adequacy in meeting objectives
  • Complete understanding and application of domain principles, concepts, practices, standards
  • Full knowledge of industry practices

Internal and External Contacts

• Interacts with internal/external personnel on project/capability

• Interfaces with internal/external personnel in own area of expertise

Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.

Spark Therapeutics does not accept unsolicited resumes/candidate profiles from any source other than directly from candidates. Any unsolicited resume/candidate profile submitted through our website or to personal email accounts of employees of Spark Therapeutics are considered property of Spark Therapeutics and are not subject to payment of agency fees.

Nearest Major Market: Philadelphia

Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.

Learn more about Spark Therapeutics and view other openings.


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