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Senior Scientist, Single Cell and Spatial Multiomics

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Closing date
May 5, 2023

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Discipline
Life Sciences, Cell Biology, Health Sciences, Drug Development
Position Type
Full Time
Job Type
Senior Scientist
Organization Type
Pharma
ROLE SUMMARY

We are seeking a motivated and dynamic individual to join the Cellular Genomics Group in Systems Immunology, part of the Inflammation & Immunology Research Unit. This person will be responsible for devising, verifying, and executing single-cell spatial transcriptomic and proteomic platforms to support drug development in Inflammation and Immunology's portfolio areas. Specifically, this role will carry out the lab and analysis components (i.e. wet and dry lab work) of in-house single-cell spatial 'omics projects, including the design and execution of lab experiments, computational analysis of generated data, and preparation of related records and reports. The successful candidate must have experience in sample collection, routine Next Generation Sequencing (NGS) processes, molecular biology, and bioinformatic analysis related to single-cell spatial sequencing. The perfect candidate will demonstrate close attention to detail, effective reasoning, and problem-solving competencies in experimental design.

ROLE RESPONSIBILITIES
  • Support the growth of single-cell spatial multiomic technology in drug development by engaging in the development, execution, validation, and troubleshooting of single-cell and spatial multiomic assays, including single-cell sequencing and single cell spatial analysis (e.g. 10X Visium or Xenium /Vizgen MerScope/Nanostring GeoMx or CosMx).
  • Perform operations of single cell/spatial analysis workflows; from tissue storage, sample preparation, data generation, and analysis for the interpretation of results, ensuring high level of quality and reliability of results produced.
  • Implement testing and optimization of tissue stabilization, embedding, sectioning, dissociation, and purification protocols.
  • Leverage advanced computational and statistical methods to analyze complex spatial multiomic datasets, facilitating the discovery of new therapeutic targets, enhancing comprehension of disease mechanisms and causal pathways, and aiding drug development.
  • Optimize and troubleshoot multiomic spatial library preparation.
  • Utilize available resources to achieve timely execution of projects and collaborate with cross-functional teams (internal and external) to execute plans and deliverables.
  • Serve as a knowledgeable resource for spatial & single-cell analysis technology, provide guidance on experimental design, method or platform selection, data analysis, and interface with in-house imaging and spatial specialists.
  • Educate other scientists, provide hands-on training, and give internal and external presentations.
  • Learn various spatial & single-cell analysis platforms, remain knowledgeable of scientific and technical innovations, and follow new trends and developments in genomic technologies to uphold the department's competitive advantage.
  • Compose experimental plans, validation reports, work instructions and SOPs.


BASIC QUALIFICATIONS
  • PhD in Biology or other related discipline with 0-3 years of experience or MS with 5+ years of relevant molecular and cellular biology experience
  • Extensive hands-on molecular biology protocol and NGS technology expertise required
  • Must have at least 3 years of documented hands-on (wet lab) experience with NGS assay development, validation, troubleshooting, and reviewing of sample QC data
  • Must have in-depth knowledge with different standard NGS platforms pipelines, as well as bioinformatics skills, including programing in R/python (or any other language), experience with command line, and familiarity with statistical software packages.


PREFERRED QUALIFICATIONS
  • 1+ year of hands-on spatial transcriptomics & single-cell sequencing experience (data generation and analysis)
  • Previous experience with tissue sectioning and high-throughput in situ hybridization and/or immunohistochemistry
  • Extensive knowledge of spatial transcriptomics platforms (10X Visium or Xenium/ Vizgen MerScope/ Nanostring GeoMx or CosMx) is greatly preferred.
  • Experience with computational and statistical approaches for high-dimensional data analysis is a plus.


\nRelocation support available\n
Work Location Assignment: Flexible

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Relocation assistance may be available based on business needs and/or eligibility.

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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