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Senior Principal Scientist , Biopharmaceutics, Drug Product Design

Groton, Connecticut
Closing date
Mar 28, 2023

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Health Sciences, Drug Development
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
We are seeking a Senior Principal Scientist in Biopharmaceutics with expertise in the development and utilization of innovative experimental and computational techniques in physical chemistry, pharmaceutics, and biophysical chemistry. This Senior Principal Scientist position is in Groton, CT- USA and will report to the US team leader in the Biopharmaceutics Group within the Drug Product Design department.

The selected candidate will lead a team of scientists to design and conduct appropriate in vitro and in silico experiments to inform the biopharmaceutics profile of drug products . The candidate should have demonstrated experience in developing novel and innovative experimental approaches to enable design and evaluation of biopharmaceutics aspects for oral drug delivery systems.

The Senior Principal Scientist will be expected to direct the research of their team members to address the challenges of generating physicochemical data to accurately describe the characteristics of complex delivery systems and utilization of this data to inform bio-performance predictions using in silico, modeling tools. The Senior Principal Scientist will be accountable for developing and delivering end-to-end translational biopharmaceutics strategy for the portfolio.

The candidate is accountable for supporting the personal growth of staff as well as providing scientific direction and operational oversight of the US based Translational Biopharmaceutics Team. The selected candidate should have interest across all aspects of biopharmaceutics through professional bodies, established external research collaborations/consortia, publications, and keynote addresses.

Role Responsibilities
  • Cultivates sustainable and effective relationships with the global biopharmaceutics group including the US based leaders of biopharmaceutics and global leader of biopharmaceutics
  • Enables seamless collaboration within translational biopharmaceutics team members and team principals across all US based Drug Product Design sites to ensure alignment and shared learning from the development of portfolio projects and new technologies.
  • Builds collaborative relationships, communicate well to influence within a matrix environment, with senior leaders across the Material Sciences Group and Formulation & Process Design Groups in DPD.
  • Provides strategic guidance and direction for direct reports, manages resource capacity along with prioritizing workload appropriately, ensures budgetary targets are met
  • Enables development of talent, succession planning and personal development of direct reports as well as for global biopharmaceutics staff in the Biopharmaceutics group across all DPD sites
  • Has direct accountability for setting strategic scientific direction, deploying resources, performance assessment, goal setting, and development discussions for the Translational Biopharmaceutics team members based in Groton, CT
  • Takes appropriate business risks to achieve desired results, ensuring safety and project delivery during all stages of development.
  • Enables or provides strategic direction for new experimental methodologies and new technologies and/or utilization of computational predictive tools to address future needs
  • Leads the group through change, ambiguity and without all the information needed. Seeks continuous improvement for self and responds to changes in both internal and external environment
  • Leads the conversation through an excellent external profile and is a recognized authority in the field.

Basic Qualifications
  • Advanced degree (PhD) or equivalent in Biopharmaceutics, Pharmaceutics, Clinical Pharmacology, Pharmaceutical Chemistry, Chemistry, Analytical Chemistry, Physical Chemistry, Chemical Engineering or Life Sciences and 8-10 years of post-degree experience in pharmaceutical industry.
  • BSc/MSc in Pharmaceutics, Chemistry, or related discipline with 15-20 years relevant pharmaceutical industry experience in small molecule drug molecule selection and drug product design.
  • Technical and people management experience in supporting all staged of drug discovery, development, and successful registration of new medicines.
  • Experience leading and collaborating with multifunctional, multi-disciplinary teams and working across matrixed cross site and global teams.
  • Track record of supporting creativity, innovation, and development of new capabilities.

Preferred Qualifications
  • Knowledge, experience and understanding of all scientific aspects of the end-to-end influence of biopharmaceutics in the drug development and registration process. Experience and expertise in the whole drug product development process with particular emphasis on biopharmaceutics risk management to successfully guide teams at all stages of drug development
  • Ability to communicate and engage with key stakeholders to anticipate and address drug delivery needs for the future portfolio and troubleshoot biopharmaceutics issues of drug products
  • Delivered innovative scientific solutions that have made significant impact to the understanding and/or predicting biopharmaceutics risk and identify pragmatic risk mitigation strategies
  • Ability to partner, mentor and manage a group of scientists with a wide range of experience and expertise, managed situations of ambiguity, work in matrixed cross site and global teams
  • Experienced overseeing day-to-day operational and strategic scientific decisions for the translational biopharmaceutics team. Committed to personal development and scientific growth of all staff.
  • A proven track record in identifying, recruiting, and development of translational biopharmaceutics talent
  • Thoughtful and inclusive decision making and whose opinions and recommendations are valued by peers, senior management, governance, and advisory bodies.
  • Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop, and coach others, oversee, and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.


Up to 10% travel requested

Relocation support available

Work Location Assignment:On Premise



Relocation assistance may be available based on business needs and/or eligibility.


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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