Senior Scientist, RNAi

Job Description

6000! This is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients. The Biotherapeutic Engineering and Gene Therapy (BEGT) group is a part of the NIBR Biologics Center (NBC). BEGT drives a diverse portfolio of modalities including therapeutic proteins, multi-specific antibodies, CAR-T, RNAi therapeutics, AAV and lentiviral vectors. NBC works collaboratively with disease area groups to broaden the use of biologics in therapeutic applications.

We have an opportunity for a Senior Scientist to join our team in Cambridge, MA. In this role, you will work on primary and immortalized cell culture systems to evaluate RNA interference (RNAi) for potency, stability, and specificity in hepatic and extra hepatic pathological implications. As a key contributor in a dynamic and multidisciplinary team, you will be involved in the development of RNAi platforms to identify drug candidates and further optimize lead candidates in close collaboration with partner teams at NIBR.

What you’ll be doing: Your responsibilities include, but are not limited to:
• Provide key biology expertise throughout discovery and development stages in RNAi. Explore new technologies and find creative solutions to optimize current platform.
• Design and lead cell-based and molecular biology strategies for target validation from medium to high throughput screenings.
• Work collaboratively internally and with CROs to run genome wide assessments of drug candidates.
• Present scientific interpretation in project team meetings and prepare data for presentations to a variety of audiences.

Diversity & Inclusion / EEO

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum Requirements

What you’ll bring to the role (required):
• B.S./M.S. with 5-8+ years relevant experience in Molecular/Cell Biology or Biochemistry or related field in industry.
• Proficiency in mammalian cell culture and primary cell culture assays and hands on experience on RT-qPCR, RNA isolation, protein, ELISA, NGS.
• Experience in design and lead cell-based assays, collaborate internally and externally with CROs to meet deadlines in fast changing environment.

Desirable:
• Desirable to have a strong knowledge and track record of accomplishment in the field of RNAi.
• Experience in data analysis of Next Generation Sequencing (NGS); bioinformatic skills considered advantageous.

Why Novartis
766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

The pay range for this position at commencement of employment is expected to be between Senior Scientist I: $92,800-139,200, Senior Scientist II: $102,400-153,600 a year, however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network