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New Therapeutic Modalities (NTM) Intern

Spark Therapeutics
Philadelphia, Pennsylvania. Hybrid and remote options available for select opportunities.
Salary not provided
Closing date
Apr 5, 2023

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Life Sciences, Biotechnology
Organization Type

Job Details

The internship within the New Therapeutic Modalities team is a laboratory-based position with tremendous learning potential in the areas of gene delivery and immunology. The intern will work on strategies to improve efficacy and tolerability of novel gene therapies. Under the guidance of Spark scientists, the intern will:

- Design and develop in vitro assays to evaluate the immunogenicity of novel vector formulations.

- Evaluate strategies to improve the efficacy of vector formulations.

- Design, plan, and execute experiments to evaluate scientific hypotheses.

- Perform cell culture, cell-based assays, and molecular biology assays.

- Present data at internal team meetings.


% of Time

Job Function and Description


Hands-on laboratory work


Data analysis and troubleshooting


Participate in group discussions, meetings

Education and Experience Requirements

Enrolled in a Bachelor’s program

  • At least 2 years left of a combination of undergraduate and/or graduate coursework with summer availability (e.g., rising junior, or rising senior pursuing graduate school)
  • Currently enrolled in an accredited college/university
  • Majoring in a biology-related degree
  • Minimum availability of 10 weeks (about 2 and a half months)
  • Participation in student organizations and/or other leadership experience

Key Skills, Abilities, and Competencies

  • Self-motivated and proactive in learning
  • Demonstration of agile mindset
  • Excellent verbal and written communication skills
  • Willingness to lead
  • Demonstrated interest in biotechnology and gene therapy industry

Complexity and Problem Solving

  • Data analysis and interpretation

Internal works within the New Therapeutic Modalities team

Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.

Spark Therapeutics does not accept unsolicited resumes/candidate profiles from any source other than directly from candidates. Any unsolicited resume/candidate profile submitted through our website or to personal email accounts of employees of Spark Therapeutics are considered property of Spark Therapeutics and are not subject to payment of agency fees.

Nearest Major Market: Philadelphia

Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.

Learn more about Spark Therapeutics and view other openings.


At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

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