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Scientist, LCMS Biomeasures

Employer
Pfizer
Location
Andover, Massachusetts
Salary
Competitive
Closing date
Mar 27, 2023

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Discipline
Health Sciences, Drug Development
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
Pharma
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best - in - class medicines to patients around the world.

What You Will Achieve

Join us as a Scientist for this exciting opportunity in the LCMS Biomeasures group in Pfizer Andover applying protein LCMS bioanalysis to transformative mRNA/LNP and biotherapeutics projects. You will primarily develop protein mass spectrometry and targeted proteomics assays to measure concentrations and turnover of targets of biotherapeutics in a variety of biological matrices as well as transgene protein expression from mRNA-LNP therapies. This is an opportunity to leverage your expertise in sample preparation and enrichment techniques including protein and peptide immunoaffinity in conjunction with LCMS-based detection using high resolution and triple quadrupole MS. The measured parameters from preclinical studies or human specimens are input parameters to mechanistic models supporting target evaluation, dose, or efficacy projections. You will join a state-of-the-art laboratory with deep expertise in protein quantification by mass spectrometry. As a member of the LCMS team, you are expected to build strong collaborative partnerships, both within and outside the group, and work in project teams and interacts with modelling & simulation experts, project leads, biologists, and protein engineers.

How You Will Achieve It
  • Develop, qualify and implement transgene protein, target biomeasure and pharmacodynamic biomarker assays using mass spectrometry in support of discovery and translational projects.
  • Work with group lead or other biomeasure team members and project team members to accomplish goals.
  • Participate in technology development and implementation by exploring new workflows to expand the group's biomarker bioanalytical capabilities.
  • Participate in all phases of mass spectrometry laboratory operations including technology evaluations, the development of sample preparation and separation methods, data analysis, interpretation, reporting and follow up discussions with the project teams on utilizing the data in appropriate decision making.
  • Ensure all tasks and responsibilities are carried out according to scientific and ethical standards e.g. responsible for electronic notebook record keeping; QC and peer review of data and reports.


Qualifications

Must-Have
  • MS with have 4+ years of relevant work experience, ideally mostly in industry OR BS Degree with 6+ years of experience.
  • Expertise in development, characterization, and implementation of bioanalytical LCMS assays.
  • Experience in the operation and troubleshooting of LCMS instrumentation and associated operating/data analysis software including Skyline, Analyst and Xcalibur.
  • Knowledge of biological sample preparation procedures for mass spectrometry.
  • Knowledge of protein biochemistry.


Nice-to-Have
  • Expertise in quantitative tissue bioanalysis and extraction methodologies of large molecules.
  • Expertise in biological sample preparation techniques (immunoaffinity, tryptic digestion, tissue processing, conjugation, etc) of various biofluids
  • Ability to work both independently and as part of a team, multitasking multiple programs.


NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
  • Lab based position requiring performing all typical laboratory related activities.
  • Based in Andover
  • Occasional travel to Cambridge (Kendal Square) is required, depending on project needs.


Other Job details

Work Location Assignment:
  • On Premise colleagues work in a Pfizer site because it's needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.


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Relocation assistance may be available based on business needs and/or eligibility.

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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