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Principal Scientist: Leukocyte-Tissue Interface, I&I Research Unit

Cambridge, Massachusetts
Closing date
Mar 30, 2023

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Health Sciences, Drug Development
Position Type
Full Time
Job Type
Research Scientist, Staff Scientist
Organization Type
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.


The Leukocyte-Tissue Interface (LTI) group is looking for a highly-motivated Principal Scientist to join a multi-disciplinary discovery group tasked with developing a cutting-edge, collaborative research program on the interactions of parenchymal tissues with resident and infiltrating leukocytes as applied to diseases in areas of Inflammation, Internal Medicine, Anti-Infectives, and Oncology that will have cross-research unit impact and delivery.

Specifically, the Principal Scientist will support a new cross-disciplinary team of scientists with expertise in Anti-Infectives that leverages cross-research unit science and expertise to support the development of novel therapeutics at the intersection between immunology and these respective disciplines. He/She will effectively and rapidly advance the biologic foundation in breaking areas of science using cutting edge technologies including optical microscopy and high content screening, systems immunology and single cell RNA techniques (scRNAseq, spatial transcriptomics, perturb-seq). The Principal Scientist will be responsible for establishing and maintaining collaborations between the Inflammation and Immunology and Anti-Infectives Research Units, as well as preparing and presenting new targets packages for potential portfolio entry.


  • Liaise with partners in the collaborating research unit to identify key areas of biology for new targets discovery.
  • Utilize diseased tissues, sourced from experimental animal models and biopsies obtained from patients to better understand tissue-immune system cross-talk,
  • Prepare proposals identifying novel drug targets to selectively modulate pathologic tissue states.
  • Integrate internal and external datasets to identify potential targets and support the development novel portfolio projects within the Inflammation and Immunology and Anti-Infectives Research Units.
  • Ensure scientific excellence in the design, execution, analysis, and interpretation of experiments in the context of applied research.
  • Guarantee that data generation, analysis, and retention is handled in a compliant manner ensuring the highest quality and integrity of findings.
  • Support the basic science effort at Pfizer by delivering quality assays and datasets to support the development new portfolio programs.
  • Contributes to the delivery of a required number of new assays, platforms, and portfolio programs per year of high quality.
  • Influences the global external environment through participation at national and international meetings and visible and active engagement with key scientific opinion leaders to ensure the group makes the appropriate investments.
  • Champions projects generated internally, via external collaborations, collaboration with Pfizer's Center for Therapeutic Innovation (CTI), or from unique partnering opportunities, thus ensuring a robust and competitive portfolio of programs and platforms for IIRU and the partnering RUs.

  • Ph.D. or equivalent training.
  • 5-7 years of relevant research experience in discovery science.
  • Preferred minimum 3 years of experience in pharmaceutical R&D.
  • Strong working knowledge of medical issues, immunology and inflammation - specifically anti-viral innate immunity.
  • Demonstrated ability to work across functions and lines in a matrix environment.
  • Combines knowledge from multiple sources to generate novel and high impact ideas. Gets to the core of the problem, asks insightful and probing questions and gets to the next steps effectively.
  • Record of delivering quality assays and datasets that empower the generation of new programs.
  • Demonstrated ability to apply knowledge, techniques and skills to identify new, 'druggable' targets.
  • Established history of working well in a team environment and collaborating with other scientists to complement individual areas of expertise with partner capabilities.
  • Strong communication and presentation skills. Ability to disseminate complex scientific findings in a concise manner to a broad audience.

Preferred Qualifications
  • Experience in select core biology themes including the interplay between host immunity and viral pathogens.
  • Expertise in respiratory disorders and pathologies
  • Ability to work with and integrate large datasets in order to identify core pathways and targets of therapeutic interest to the department.
  • Background in the intersection of Inflammation and Viral Biology.

\nRelocation support available\n
Work Location Assignment: Flexible


Relocation assistance may be available based on business needs and/or eligibility.


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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