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Research Associate - Electrophysiology and Voltage Imaging

Baylor College of Medicine
Houston, Texas
Closing date
May 12, 2023

View more

Life Sciences, Neuroscience
Position Type
Full Time
Job Type
Research Scientist
Organization Type

The St-Pierre lab develops and applies new tools for monitoring and interrogating brain activity with millisecond-timescale temporal resolution. We seek an energetic team member to lead our efforts to characterize and apply new light-responsive proteins in vitro and in vivo. The Research Associate will work on two types of tools: (1) genetically encoded voltage indicators (GEVIs), fluorescent biosensors that report voltage as changes in brightness, and (2) optogenetic silencers, light-gated channels that inhibit neuronal firing. Characterization of these tools requires simultaneous electrophysiological recordings and optical excitation/imaging. This position provides exciting opportunities to work with the latest optical technologies and develop new skills in two-photon voltage imaging, protein engineering, and synthetic biology.

Job Duties

  • Culture mammalian cells
  • Prepare brain slices, dissociated neurons, or both
  • Conduct experiments that combine electrophysiology and either optogenetic activation or optical imaging (multi-photon fluorescence microscopy)
  • Maintain reagent and tool supply related to the experiments
  • Maintain an electrophysiological rig, and troubleshooting if needed
  • Analyze data using commercial software or customized data pipelines
  • Teach techniques, procedures, and experimental design to other members of the lab
  • Communicate research results in group meetings, national or international conferences

Minimum Qualifications

  • Master's degree in Basic Science or a related field. Experience in lieu of degree will not be accepted.
  • Three years of relevant experience typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.

Preferred Qualifications

  • PhD
  • Experience with electrophysiology

Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.



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