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Associate Scientist, Protein Sciences

Groton, Connecticut
Closing date
May 4, 2023

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Health Sciences, Drug Development
Position Type
Full Time
Job Type
Staff Scientist
Organization Type
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best - in - class medicines to patients around the world.

What You Will Achieve

Pfizer currently has an open Associate Scientist position for a protein biochemist in the Structural and Molecular Sciences (SMS) department in Groton, CT. We are seeking a highly motivated individual with strong expertise in recombinant protein purification and characterization and the desire to pursue challenging biomolecular targets for drug discovery. We are an integrated and highly collaborative team of colleagues with technical expertise in molecular biology, protein biochemistry, biophysics, and structural biology. We have a strong track record of enabling hit-to-lead progression for small molecule modulators of both soluble and integral membrane proteins using integrated biochemical, biophysical, and structural approaches. We actively collaborate with Pfizer drug discovery teams across diverse therapeutic areas including Immunology & Inflammation, Internal Medicine, Vaccines, and Infectious Diseases, with a mission to advance drug and vaccine discovery efforts by providing comprehensive molecular and structural understanding of the therapeutic targets, lead molecules, and protein-ligand interactions.

The successful candidate will join a team of top-notch scientists focused on first-in-class targets structural studies for structure-based drug discovery.

How You Will Achieve It
  • Purify functional proteins or protein complexes for biochemistry, biophysics, and structure determination (both x-ray and cryo-EM).
  • Perform construct screening for novel targets to enable structural determination and SBDD by x-ray and cryo-EM
  • Characterize proteins by analytical and biophysical methods including western blot, aSEC, DLS, TSA, and MS to monitor stability, conformation, modification, and oligomerization.
  • Learn and apply various biophysical approaches to enable hit identification, validation, target engagement, and Mechanism-of-Action studies.
  • Be part of multi-disciplinary teams to support discovery projects across diverse disease areas.
  • Effective oral and written communication of experimental work and analysis.
  • Perform timely notebook entries and review for completed experiments.


  • BS with 0-3 years of relevant laboratory experience required.
  • Proficient skills in recombinant protein purification using different methods.
  • Experience in analytical protein characterization by aSEC, SDS-PAGE, Western Blot, and protein concentration determination.
  • Working experience on recombinant gene-to-protein pipeline.
  • Ability to learn, adapt, and thrive in light-speed and highly dynamic working environment.
  • Ability to multi-task to balance parallel activities.
  • Ability to troubleshoot scientific and technical challenges and contribute to their resolution.
  • Excellent communication skills, both verbal and written .
  • Experience with data analysis and presentation software.

  • Experience with both soluble and membrane proteins is desirable.
  • Experience with protein purification for cryo-EM analysis is a plus.
  • Experience with biophysical assays to investigate protein/small molecule interactions (ex: TSA) is a plus.
  • Experience of working on a team in multidisciplinary research environment is desirable.

Other Job Details
Work Location Assignment:On Premise. C olleagues work in a Pfizer site because it's needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site


Relocation assistance may be available based on business needs and/or eligibility.


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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