Senior Scientist, Structural & Molecular Sciences

Groton, Connecticut
Closing date
Mar 28, 2023

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Life Sciences, Molecular Biology, Health Sciences, Drug Development
Position Type
Full Time
Job Type
Senior Scientist
Organization Type
Pfizer seeks a highly motivated and experienced scientist to join our Groton, CT cryo-EM group. The successful candidate will bring strong expertise in molecular biology, protein expression, protein purification, and biophysical protein characterization across multiple modalities to produce and characterize high-quality reagents for structure determination and biochemical analyses.

Our group employs a state-of-the-art cryo-EM facility to determine high-resolution structures of proteins, protein-protein and protein-ligand complexes, and other macromolecular assemblies to elaborate molecular mechanisms and drive structure-based drug design. A key requirement of this position will be the thorough characterization and optimization of challenging protein targets, using a variety of biochemical and biophysical techniques, both to provide insights to project teams and to enable high-resolution protein structures by cryo-EM.

As a member of our high-performing team, you will collaborate with biologists and chemists from across Pfizer to provide support for internal drug discovery programs at various stages of development. Excellent oral and written communication skills are essential, and job responsibilities will include regularly preparing and presenting results in the context of multi-disciplinary project teams. The successful candidate will be team-oriented and will be expected to draw from their expertise to actively participate in project teams and make contributions to inform decision-making on active drug discovery projects. Pfizer offers many opportunities for scientific and career development, including exploration of novel biology and cutting-edge techniques, as well as potential for leadership.

  • Establish productive collaborations with other colleagues and form partnerships with colleagues from research units and other departments.
  • Rapidly advance projects by timely problem solving and crisp decision making.
  • Clearly communicate with project team members and other Pfizer colleagues.
  • Consistently record your experimental results in an electronic laboratory notebook and comply with all Pfizer safety policies.

  • Ph.D. or equivalent degree in biology, biochemistry, or biophysics or related field, with at least 2 years of postdoctoral experience and a solid record of high-quality publications.
  • Excellent molecular biology, protein expression and purification skills, including construct engineering, expression in multiple hosts, and purification using chromatographic techniques. Proven ability to troubleshoot and optimize difficult targets, including membrane proteins.
  • Hands-on expertise in methods of protein characterization, including analytical SEC, light scattering, mass spectrometry, and others. Experience with a variety of biophysical methods is desirable.
  • Experience with X-ray crystallography and/or electron microscopy is desirable, but not required. Candidates should have a working knowledge of protein structure.
  • Excellent communication skills
  • Good interpersonal skills, with the ability to work well with others in teams and foster collaboration.

Additional Information:
  • Relocation support available
  • Eligible for Employee Referral
  • Work Location Assignment:Onsite
  • Last Day to Apply: April 9, 2023


Relocation assistance may be available based on business needs and/or eligibility.


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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