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Associate Data Scientist (Dr. Pavan Bachireddy's Lab)

University of Texas MD Anderson Cancer Center
Houston, Texas
Closing date
Apr 6, 2023

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Health Sciences
Organization Type

Job Details

We are seeking a talented and highly motivated Associate Data Scientist interested in understanding the co-evolutionary interactions between cancer and immune cells in the tumor microenvironment. Our lab uses unbiased, high-dimensional technologies to decode the rules of interaction among diverse cell types in the tumor milieu that determine patient outcomes to cancer immunotherapy, primarily in hematologic malignancies.

Caring: By our words and actions we demonstrate caring toward everyone.

Integrity: We work together with professionalism to merit the trust of our colleagues and those we serve in all that we do.

Discovery: We embrace creativity and seek new knowledge from diverse perspectives.

Safety: We provide a safe environment - physically and psychologically - for our patients, for our colleagues and for our community.

Stewardship: We protect and preserve our institutional reputation and the precious resources - people, time, financial and environmental - entrusted to us.

Analyze Next-generation Sequencing Data and Deploy Immunogenomic Tools:
**Run somatic mutation, copy number and transcriptional alteration pipelines on matched tumor/normal pairs whole exome/genome and RNA-seq data. **Run clonality estimation and mutational phylogeny inference tools. **Perform single-point and serial analysis of single-cell RNA-seq, ATAC-seq, CITE-seq and TCR/BCR-seq data. **Create pipelines comprising a wide-ranging suite of in-house and external immune deconvolution, HLA inference, neoantigen prediction, T- and B-cell repertoire analysis software. **Write custom scripts to improve immunogenic methods developed in the lab. Package tools using Docker and Conda applications.

Assisting & Teaching Others:
*Assists in the analysis and development of formalisms, algorithms and software. *With direction, develops and maintains software tools and infrastructure for resolving specific problems. *Maintains pipelines for analysis of sequencing data. *Contributes to the development of procedures and makes recommendations on new procedures; contributes to intellectual atmosphere through journal clubs, sharing of ideas and constructive feedback on others' presentations, and collaboration.

Support Ongoing Research Projects:
**Provide bioinformatic and basic statistical support to ongoing research projects including differential gene expression/mutation analysis, gene set enrichment and pathway analysis, custom sequence alignments etc. **Download and analyze publicly available datasets such as TCGA, CCLE, GTEx and GEO. **Generate custom visualizations of analytical results. **Organize data and document and code developed for each project **Other duties as assigned.

Analytical Thinking - Gather relevant information systematically; break down problems into simple components; make sound decisions.

Innovative Thinking - Approach problems with curiosity and open-mindedness; offer new ideas, solutions and/or options.

Technical/Functional Expertise - Demonstrate technical proficiency required to do the job; possess up-to-date knowledge in the profession; provide technical expertise to others.

Service Orientation
Provide service to our stakeholders, including patients, caregivers, colleagues and each other, in a safe, courteous, accountable, efficient and innovative manner to include:
• Promoting inclusiveness and collegiality that demonstrates respect and professionalism to our stakeholders at all times
• Modeling safe, ethical behavior that mitigates risk to the institution through sound business practices, and adherence to MD Anderson's Standards of Conduct, institutional policies and procedures
• Responding to requests in a timely manner while proactively communicating expectations for procedures, service arrival, or project deliverables to stakeholders
• Using the steps to HEAL (Hear, Empathize, Address and Learn) the relationship when service recovery is needed

Bachelor's degree in Biomedical Engineering, Electrical Engineering, Computer Engineering, Physics, Applied Mathematics, Statistics, Computer Science, Computational Biology, or related field. Two years experience in scientific software development/analysis. It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.


The University of Texas MD Anderson Cancer Center in Houston is one of the world's most respected centers focused on cancer patient care, research, education and prevention. It was named the nation's No. 1 hospital for cancer care in U.S. News & World Report's 2023 rankings. It is one of the nation's original three comprehensive cancer centers designated by the National Cancer Institute.

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